The development of allergic inflammation.

The development of allergic inflammation.
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DOI:
10.1038/nature07204
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发表时间:
2008-07-24
期刊:
影响因子:
64.8
通讯作者:
Piliponsky, Adrian M.
Piliponsky, Adrian M.
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Galli, Stephen J.;Tsai, Mindy;Piliponsky, Adrian M.

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过敏性疾病,如过敏反应、花粉热、湿疹和哮喘,现在折磨着发达国家大约25%的人。在过敏受试者中,持续或重复暴露于过敏原(通常是环境中常见的本质上无害的物质)会导致慢性过敏性炎症。这反过来又导致受影响器官结构的长期变化和功能的实质性异常。因此,了解急性和慢性过敏性炎症的特征和后果,特别是探索肥大细胞如何促成这种免疫反应性不良模式的几个特征是很重要的。
Allergic disorders, such as anaphylaxis, hay fever, eczema and asthma, now afflict roughly 25% of people in the developed world. In allergic subjects, persistent or repetitive exposure to allergens, which typically are intrinsically innocuous substances common in the environment, results in chronic allergic inflammation. This in turn produces long-term changes in the structure of the affected organs and substantial abnormalities in their function. It is therefore important to understand the characteristics and consequences of acute and chronic allergic inflammation, and in particular to explore how mast cells can contribute to several features of this maladaptive pattern of immunological reactivity.
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