The Use of Drosophila to Understand Psychostimulant Responses.
The Use of Drosophila to Understand Psychostimulant Responses.
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利用果蝇来理解心理刺激反应。
DOI：
10.3390/biomedicines10010119
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发表时间：
2022-01-06
期刊：
影响因子：
4.7
通讯作者：
Titos I
中科院分区：
文献类型：
--
作者：
Philyaw TJ;Rothenfluh A;Titos I
可卡因、苯丙胺、甲基苯丙胺和哌醋甲酯等精神兴奋剂的成瘾特性是基于它们在奖赏系统中增加多巴胺能神经传递的能力。虽然可卡因和甲基苯丙胺主要用于娱乐，但苯丙胺和哌醋甲酯也可作为有效的治疗剂来治疗包括注意力缺陷和多动障碍（ADHD）和自闭症谱系障碍（ASD）在内的疾病症状。虽然精神兴奋剂药物的成瘾特性及其治疗效果都受到遗传变异的影响，但很少有基因在人类中调节这些过程。这在很大程度上是由于人口异质性，这需要大量的样本。黑腹果蝇表现出与人类相似的精神兴奋反应，高度的基因保守性，并允许在大种群中进行行为测定。此外，安非他明和哌醋甲酯减少了ADHD样行为的苍蝇模型的损伤。因此，果蝇是一个理想的翻译模式生物，以解决精神兴奋剂的影响背后的遗传成分。在这里，我们打破了许多可靠的量化可卡因，安非他明，甲基苯丙胺和哌醋甲酯在果蝇中的影响的测定。我们还讨论了如何果蝇是一个有效的和具有成本效益的模式生物识别新的候选基因和分子机制参与精神兴奋剂药物的行为反应。
The addictive properties of psychostimulants such as cocaine, amphetamine, methamphetamine, and methylphenidate are based on their ability to increase dopaminergic neurotransmission in the reward system. While cocaine and methamphetamine are predominately used recreationally, amphetamine and methylphenidate also work as effective therapeutics to treat symptoms of disorders including attention deficit and hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Although both the addictive properties of psychostimulant drugs and their therapeutic efficacy are influenced by genetic variation, very few genes that regulate these processes in humans have been identified. This is largely due to population heterogeneity which entails a requirement for large samples. Drosophila melanogaster exhibits similar psychostimulant responses to humans, a high degree of gene conservation, and allow performance of behavioral assays in a large population. Additionally, amphetamine and methylphenidate reduce impairments in fly models of ADHD-like behavior. Therefore, Drosophila represents an ideal translational model organism to tackle the genetic components underlying the effects of psychostimulants. Here, we break down the many assays that reliably quantify the effects of cocaine, amphetamine, methamphetamine, and methylphenidate in Drosophila. We also discuss how Drosophila is an efficient and cost-effective model organism for identifying novel candidate genes and molecular mechanisms involved in the behavioral responses to psychostimulant drugs.
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影响因子：
4.8
作者：
Beumer, Kelly J.;Carroll, Dana
通讯作者：
Carroll, Dana
与奖励相关行为中的多巴胺信号传导。
影响因子：
3.5
作者：
Baik JH
通讯作者：
Baik JH
影响因子：
5
作者：
Cadoni, C;Solinas, M;Di Chiara, G
通讯作者：
Di Chiara, G
影响因子：
11.1
作者：
Cartier, Etienne;Hamilton, Peter J.;Belovich, Andrea N.;Shekar, Aparna;Campbell, Nicholas G.;Saunders, Christine;Andreassen, Thorvald F.;Gether, Ulrik;Veenstra-Vanderweele, Jeremy;Sutcliffe, James S.;Ulery-Reynolds, Paula G.;Erreger, Kevin;Matthies, Heinrich J. G.;Galli, Aurelio
通讯作者：
Galli, Aurelio
影响因子：
64.5
作者：
Bainton, RJ;Tsai, LTY;Heberlein, U
通讯作者：
Heberlein, U