Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses.
Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses.
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DOI：
10.1038/s41590-022-01222-1
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发表时间：
2022-06
影响因子：
30.5
通讯作者：
Andrabi, Raiees
中科院分区：
文献类型：
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作者：
He, Wan-ting;Musharrafieh, Rami;Song, Ge;Dueker, Katharina;Tse, Longping V.;Martinez, David R.;Schafer, Alexandra;Callaghan, Sean;Yong, Peter;Beutler, Nathan;Torres, Jonathan L.;Volk, Reid M.;Zhou, Panpan;Yuan, Meng;Liu, Hejun;Anzanello, Fabio;Capozzola, Tazio;Parren, Mara;Garcia, Elijah;Rawlings, Stephen A.;Smith, Davey M.;Wilson, Ian A.;Safonova, Yana;Ward, Andrew B.;Rogers, Thomas F.;Baric, Ralph S.;Gralinski, Lisa E.;Burton, Dennis R.;Andrabi, Raiees
当前 SARS-CoV-2 相关变种 (VOC) 的出现以及未来 SARS 样冠状病毒可能向人类蔓延，对人类健康和全球经济构成重大威胁。需要开发能够减轻这些威胁的广泛有效的冠状病毒疫苗。在这里，我们利用有针对性的供体选择策略来分离一大组针对 sarbecovirus 的人类广泛中和抗体 (bnAb)。许多 bnAb 在中和多种 sarbecovirus 和大多数 SARS-CoV-2 VOC（包括 Omicron 变体）方面非常有效。中和宽度是通过 bnAb 与受体结合结构域 (RBD) 相对保守的面上的表位结合来实现的。与保守位点的靶向一致，选定的 RBD bnAb 在预防挑战模型中表现出针对多种 SARS 样冠状病毒的体内保护功效。 bnAb 为下一代抗体预防和治疗应用提供了新的机会和选择，更重要的是，为有效设计泛沙病毒疫苗提供了分子基础。
The emergence of current SARS-CoV-2 variants of concern (VOCs) and potential future spillovers of SARS-like coronaviruses into humans pose a major threat to human health and the global economy. Development of broadly effective coronavirus vaccines that can mitigate these threats is needed. Here, we utilized a targeted donor selection strategy to isolate a large panel of human broadly neutralizing antibodies-(bnAbs) to sarbecoviruses. Many of the bnAbs are remarkably effective in neutralization against diverse sarbecoviruses and against most SARS-CoV-2 VOCs including Omicron variant. Neutralization breadth is achieved by bnAb binding to epitopes on a relatively conserved face of the receptor binding domain-(RBD). Consistent with targeting of conserved sites, select RBD bnAbs exhibited in vivo protective efficacy against diverse SARS-like coronaviruses in a prophylaxis challenge model. The bnAbs provides new opportunities and choices for next-generation antibody prophylactic and therapeutic applications and, importantly, provides a molecular basis for effective design of pan-sarbecovirus vaccines.
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影响因子：
24.8
作者：
Bates TA;McBride SK;Leier HC;Guzman G;Lyski ZL;Schoen D;Winders B;Lee JY;Lee DX;Messer WB;Curlin ME;Tafesse FG
通讯作者：
Tafesse FG
影响因子：
7
作者：
Andrabi R;Bhiman JN;Burton DR
通讯作者：
Burton DR
影响因子：
64.8
作者：
Barnes CO;Jette CA;Abernathy ME;Dam KA;Esswein SR;Gristick HB;Malyutin AG;Sharaf NG;Huey-Tubman KE;Lee YE;Robbiani DF;Nussenzweig MC;West AP Jr;Bjorkman PJ
通讯作者：
Bjorkman PJ
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
DOI：
10.1126/science.abm3425
发表时间：
2022-01-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
通讯作者：
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