Low-dose apomorphine reduces serum homovanillic acid concentrations in schizophrenic patients.
Low-dose apomorphine reduces serum homovanillic acid concentrations in schizophrenic patients.
复制标题
低剂量阿朴吗啡可降低精神分裂症患者的血清高香草酸浓度。
DOI：
10.1016/0024-3205(82)90609-9
复制
发表时间：
1982
期刊：
影响因子：
6.1
通讯作者：
R. Wyatt
中科院分区：
文献类型：
--
作者：
N. Cutler;D. Jeste;F. Karoum;R. Wyatt
本研究旨在评价小剂量阿朴吗啡对人体多巴胺能自身受体的调节作用。对小剂量阿朴吗啡的行为和血清高香草酸浓度进行了研究。用质谱仪测定了5例慢性精神分裂症患者服用0.005 mg/kg阿朴吗啡或生理盐水安慰剂前后的血清高香草酸浓度。结果显示，与安慰剂相比，服用阿朴吗啡后，所有五名受试者的血清高香草酸浓度均显著降低。这些发现直接证明了小剂量阿朴吗啡对精神分裂症患者具有特定的多巴胺自身受体效应。
This study was carried out to evaluate the postulated dopaminergic autoreceptor regulatory effect in man of low-dose apomorphine. Behavior and serum homovanillic acid concentrations following low-dose apomorphine were investigated. Five medicated chronic schizophrenic patients had serum homovanillic acid concentrations measured by mass fragmentography before and after 0.005 mg/kg of apomorphine or saline placebo. Results demonstrate significant reductions in serum homovanillic acid concentrations in all five subjects following apomorphine as compared with placebo. These findings present direct evidence of a specific dopamine autoreceptor effect of low-dose apomorphine in schizophrenic patients.
人血浆中的儿茶酚胺代谢物作为脑功能的指标：异喹啉的影响。
影响因子：
6.1
作者：
Swann,AC;Maas,JW;Hattox,SE;Landis,H
通讯作者：
Landis,H