Catecholamine metabolites in human plasma as indices of brain function: effects of debrisoquin.
Catecholamine metabolites in human plasma as indices of brain function: effects of debrisoquin.
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人血浆中的儿茶酚胺代谢物作为脑功能的指标：异喹啉的影响。
DOI：
10.1016/0024-3205(80)90430-0
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发表时间：
1980
期刊：
影响因子：
6.1
通讯作者：
Landis,H
中科院分区：
文献类型：
--
作者：
Swann,AC;Maas,JW;Hattox,SE;Landis,H
血浆中的儿茶酚胺类神经递质的代谢是一种潜在的、容易获得的人脑功能指标。硫酸异喹（一种不进入大脑的单胺氧化酶抑制剂）降低了这些代谢物的外周贡献。在猴子中，已表明异喹减少多巴胺代谢物高香草酸（HVA）的外周产生，而不改变大脑的产生;去甲肾上腺素代谢物3-甲氧基-4-羟基苯乙二醇（MHPG）的产生在外周和大脑中减少。在人体中给予低剂量异喹消除了约80%的外周对血浆中HVA和MHPG的贡献，导致血浆中至少75%的这些代谢物来自脑的情况。在此条件下，血浆中HVA和MHPG具有显著相关性。还可以估计，大脑产生的MHPG减少了55%。Debrisoquin潜在地提供了一种用于通过血浆中的代谢物研究脑儿茶酚胺和用于治疗脑去甲肾上腺素能过量的病症的方法。
Metabolites of catecholamine neurotransmitters in plasma are, potentially, an easily available indicator of brain function in man. The peripheral contribution to these metabolites was lowered by debrisoquin sulfate, a monoamine oxidase inhibitor that does not enter the brain. In the monkey, it had been shown that debrisoquin decreased peripheral production of the dopamine metabolite, homovanillic acid (HVA), without changing production by brain; production of the norepinephrine metabolite, 3-methoxy-4-hydroxyphenethyleneglycol (MHPG) was decreased peripherally and in brain. Low-dose debrisoquin administration in man eliminated about 80% of the peripheral contribution to HVA and MHPG in plasma, resulting in a situation in which at least 75% of these metabolites in plasma were from the brain. Under these conditions, HVA and MHPG in plasma had a significant correlation. It could also be estimated that production of MHPG by brain was reduced 55%. Debrisoquin potentially provides a method for studying brain catecholamines through their metabolites in plasma and for treating conditions of brain noradrenergic excess.
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