Genetics of stroke recovery: BDNF val66met polymorphism in stroke recovery and its interaction with aging.
Genetics of stroke recovery: BDNF val66met polymorphism in stroke recovery and its interaction with aging.
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DOI：
10.1016/j.nbd.2018.08.009
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发表时间：
2019-06
影响因子：
6.1
通讯作者：
Cho S
中科院分区：
文献类型：
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作者：
Balkaya M;Cho S
中风会导致长期的感觉、运动和认知障碍。大多数患者都会经历一定程度的自然恢复，但这种恢复大多不完全，并且个体差异很大。恢复结果的差异归因于多种因素，包括病变大小、皮质脊髓束完整性、年龄、性别和种族。人们普遍认为，遗传因素在中风发病率中起着至关重要的作用，并且越来越多的证据表明，遗传因素也是康复过程中的一个重要决定因素。在与中风恢复相关的基因数量和变异中，BDNF 基因中的 val66met 单核苷酸多态性 (SNP) 对中风后可塑性的影响最为显着。 Val66met 是特征最明确的 BDNF SNP，在人类中很常见（亚洲人中 40-50%，白种人中 25-32%）。它减少活动依赖性 BDNF 释放，抑制皮质可塑性，并与多种疾病有关。早期关于 val66met 对中风结局和恢复影响的研究主要表现出适应不良的作用。然而，新的发现表明 val66met 和中风恢复之间存在更为复杂的相互作用，这种相互作用似乎受到病变位置、中风后阶段和年龄的影响。本综述将重点关注 BDNF 和 val66met SNP 在中风恢复中的作用，并试图确定所涉及的潜在病理生理机制。还讨论了年龄对 val66met 相关可塑性改变的影响以及中风的潜在后果。
Stroke leads to long term sensory, motor and cognitive impairments. Most patients experience some degree of spontaneous recovery which is mostly incomplete and varying greatly among individuals. The variation in recovery outcomes has been attributed to numerous factors including lesion size, corticospinal tract integrity, age, gender and race. It is well accepted that genetics play a crucial role in stroke incidence and accumulating evidence suggests that it is also a significant determinant in recovery. Among the number of genes and variations implicated in stroke recovery the val66met single nucleotide polymorphism (SNP) in the BDNF gene influences post-stroke plasticity in the most significant ways. Val66met is the most well characterized BDNF SNP and is common (40–50 % in Asian and 25–32% in Caucasian populations) in humans. It reduces activity-dependent BDNF release, dampens cortical plasticity and is implicated in numerous diseases. Earlier studies on the effects of val66met on stroke outcome and recovery presented primarily a maladaptive role. Novel findings however indicate a much more intricate interaction between val66met and stroke recovery which appears to be influenced by lesion location, post-stroke stage and age. This review will focus on the role of BDNF and val66met SNP in relation to stroke recovery and try to identify potential pathophysiologic mechanisms involved. The effects of age on val66met associated alterations in plasticity and potential consequences in terms of stroke are also discussed.
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影响因子：
8.3
作者：
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通讯作者：
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影响因子：
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通讯作者：
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影响因子：
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