Advanced carcinoma of the pancreas: phase II study of combined chemotherapy, beta-interferon, and retinoids.
Advanced carcinoma of the pancreas: phase II study of combined chemotherapy, beta-interferon, and retinoids.
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晚期胰腺癌：联合化疗、β-干扰素和类视黄醇的 II 期研究。
DOI：
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
L. Frati
中科院分区：
文献类型：
--
作者：
F. Recchia;G. Sica;D. Casucci;S. Rea;A. Gulino;L. Frati
由于胰腺癌对常规治疗的反应较差，作者进行了一项 II 期试点研究，以评估在活性化疗药物中添加 β-干扰素和类维生素A是否可以提高一组患有转移性疾病的患者的反应率和生存率。 23 名初治患者接受如下治疗：表柔比星 60 mg/m2 和丝裂霉素 C 10 mg/m2，第 1 天静脉注射；亚叶酸，200 mg/m2，和5-氟尿嘧啶（5-FU），370 mg/m2，静脉注射，连续5天。在化疗周期之间给予β-干扰素，1 x 10(6) IU/m2，皮下注射，每周三次，视黄醇棕榈酸酯，50,000 IU，口服，每天两次。使用相同剂量的β-干扰素和视黄醇棕榈酸酯维持有反应和疾病稳定的患者。每 4 周进行一次治疗，持续四个疗程或直至出现进展。每位患者平均接受三个疗程的化疗。所有患者均可进行评估。 8 名患者有反应 (35%)，8 名患者 (35%) 病情稳定。所有患者的中位进展时间和生存时间分别为 6.1 个月和 11 个月。毒性严重：60%患者出现血液毒性，40%出现胃肠道毒性，13%出现心脏毒性，1例患者出现溶血尿毒症综合征。化疗、β-干扰素和类维生素A的组合在转移性胰腺癌中显示出活性。毒性很高，但有反应且疾病稳定的患者症状缓解时间较长。
Because of the poor response of pancreatic cancer to conventional therapy, the authors performed a phase II pilot study to evaluate whether beta-interferon and retinoids, added to active chemotherapeutic agents, could increase response rate and survival in a group of patients who had metastatic disease. Twenty-three chemotherapy-naive patients were treated as follows: epirubicin, 60 mg/m2, and mitomycin C, 10 mg/m2, intravenously on day 1; folinic acid, 200 mg/m2, and 5-fluorouracil (5-FU), 370 mg/m2, intravenously for 5 consecutive days. beta-Interferon, 1 x 10(6) IU/m2, subcutaneously three times a week, and retinol palmitate, 50,000 IU orally twice a day, were given between chemotherapy cycles. Patients having responses and disease stabilization were maintained with the same dose of beta-interferon and retinol palmitate. Treatment was given every 4 weeks for four courses or until onset of progression. A median of three courses of chemotherapy was delivered to each patient. All patients were evaluable. Eight patients responded (35%) and 8 (35%) had stable disease. Median time to progression and survival for all patients were, respectively, 6.1 months and 11 months. Toxicity was severe: 60% of patients had hematologic toxicity, 40% had gastrointestinal toxicity, 13% had cardiac toxicity, and 1 patient had a hemolitic-uremic syndrome. The combination of chemotherapy, beta-interferon, and retinoids shows activity in metastatic pancreatic carcinoma. Toxicity was high but patients who had responses and disease stabilization had prolonged symptom palliation.
亚叶酸增强 5-氟尿嘧啶的抗肿瘤作用。
影响因子：
13.5
作者：
Mini,E;Trave,F;Rustum,YM;Bertino,JR
通讯作者：
Bertino,JR
低剂量与高剂量干扰素α-2a治疗复发性惰性非霍奇金淋巴瘤的比较。
DOI：
10.1093/jnci/82.3.235
发表时间：
1990
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
VanderMolen,LA;Steis,RG;Duffey,PL;Foon,KA;Smith2nd,JW;Clark,JW;Conlon,K;Stevenson,HC;Urba,WJ;Hartmann,LC
通讯作者：
Hartmann,LC