Insights into Mus musculus Population Structure across Eurasia Revealed by Whole-Genome Analysis.
Insights into Mus musculus Population Structure across Eurasia Revealed by Whole-Genome Analysis.
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通过全基因组分析揭示了欧亚大陆小家鼠种群结构的见解。
DOI：
10.1093/gbe/evac068
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发表时间：
2022-05-03
影响因子：
3.3
通讯作者：
Osada, Naoki
中科院分区：
文献类型：
--
作者：
Fujiwara, Kazumichi;Kawai, Yosuke;Takada, Toyoyuki;Shiroishi, Toshihiko;Saitou, Naruya;Suzuki, Hitoshi;Osada, Naoki
100多年来，家鼠（Mus musculus）一直被用作生物医学研究的关键动物模型。家鼠具有遗传多样性，但它们在全球范围内的遗传背景尚未完全了解。先前的研究表明，它们起源于南亚，大约在11万至50万年前几乎同时分化成三个主要亚种;然而，随着史前和历史时期现代人类的迁移，（大约10，000年前到今天），并经历了二次接触，这使得野生家鼠的遗传景观变得复杂。在这项研究中，我们对来自欧亚大陆，特别是东亚，东南亚和南亚的98只野生家鼠的全基因组序列进行了测序。虽然野生家鼠被发现由三个主要的遗传群体对应的三个主要亚种，个体代表亚种之间的混合物在东亚比以前认识到的更普遍。此外，几个样品表现出线粒体和常染色体基因组之间的系谱不一致的模式。使用样本，可能保留了原来的遗传成分的亚种与最少的混合物，我们估计的模式和时间之间的分歧亚种。三个亚种的分歧时间估计为187，000 - 226，000年前。这些结果将有助于我们了解野生小鼠在全球范围内的遗传多样性，并且这些发现将在未来的生物医学和进化研究中特别有用，这些研究涉及从这些野生小鼠建立的实验室小鼠。
For more than 100 years, house mice (Mus musculus) have been used as a key animal model in biomedical research. House mice are genetically diverse, yet their genetic background at the global level has not been fully understood. Previous studies have suggested that they originated in South Asia and diverged into three major subspecies, almost simultaneously, approximately 110,000–500,000 years ago; however, they have spread across the world with the migration of modern humans in prehistoric and historic times (∼10,000 years ago to the present day) and have undergone secondary contact, which has complicated the genetic landscape of wild house mice. In this study, we sequenced the whole-genome sequences of 98 wild house mice collected from Eurasia, particularly East Asia, Southeast Asia, and South Asia. Although wild house mice were found to consist of three major genetic groups corresponding to the three major subspecies, individuals representing admixtures between subspecies were more prevalent in East Asia than has been previously recognized. Furthermore, several samples exhibited an incongruent pattern of genealogies between mitochondrial and autosomal genomes. Using samples that likely retained the original genetic components of subspecies with the least admixture, we estimated the pattern and timing of divergence among the subspecies. The estimated divergence time of the three subspecies was 187,000–226,000 years ago. These results will help us to understand the genetic diversity of wild mice on a global scale, and the findings will be particularly useful in future biomedical and evolutionary studies involving laboratory mice established from such wild mice.
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DOI：
10.1111/j.1095-8312.1987.tb00288.x
发表时间：
1987-01-01
影响因子：
1.9
作者：
BONHOMME, F;GUENET, JL;BULFIELD, G
通讯作者：
BULFIELD, G
影响因子：
1.2
作者：
Cingolani, Pablo;Platts, Adrian;Ruden, Douglas M.
通讯作者：
Ruden, Douglas M.
DOI：
10.1111/j.1095-8312.2005.00440.x
发表时间：
2005-03-01
影响因子：
1.9
作者：
Bozíková, E;Munclinger, P;Piálek, J
通讯作者：
Piálek, J
影响因子：
3.7
作者：
Gabriel, Sofia I.;Stevens, Mark I.;Searle, Jeremy B.
通讯作者：
Searle, Jeremy B.
影响因子：
4.9
作者：
Geraldes A;Basset P;Smith KL;Nachman MW
通讯作者：
Nachman MW