Danger and distress: Parabrachial-extended amygdala circuits.
Danger and distress: Parabrachial-extended amygdala circuits.
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DOI：
10.1016/j.neuropharm.2021.108757
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发表时间：
2021-10-15
影响因子：
4.7
通讯作者：
Winder, D. G.
中科院分区：
文献类型：
--
作者：
Jaramillo, A. A.;Brown, J. A.;Winder, D. G.
我们对臂旁核（PBN）作用的理解随着技术的进步而发展，部分原因是细胞特异性研究和复杂的行为测定。这反映在PBN到扩展杏仁核（EA）回路（包括终纹床核（BNST）和中央杏仁核（CeA）回路）内的异质神经元群体中，因为它们在应对生存所需的各种威胁样环境时差异调节行为方面。在这里，我们回顾PBN→CeA和PBN→BNST通路如何通过独特的神经传递变化来调节恐惧样行为，先天的和条件性的，以应对应激诱导的情况。此外，我们假设在特定情况下，PBN→CeA和PBN→BNST回路是冗余的，并且部分地与它们各自的相互投射交织在一起。通过解构情感和压力相关行为范式的内感受性和外感受性成分，有证据表明PBN→CeA回路调节对物理刺激和恐惧条件反射的先天反应。相反，PBN→BNST回路在不可预测的情况下调节类似痛苦的压力。因此，PBN提供了一个途径，用于警告内感受性和外感受性刺激被处理并中继到EA以诱导应激相关的影响。此外，我们为未来的研究提供了一个框架，以详细说明PBN→EA回路在介导对威胁的行为反应中的细胞类型特异性复杂性，以及PBN在药物使用中的相关性，因为它与威胁和负强化有关。这篇文章是“神经回路调节药物和酒精滥用”特刊的一部分。
Our understanding of the role of the parabrachial nucleus (PBN) has evolved as technology has advanced, in part due to cell-specific studies and complex behavioral assays. This is reflected in the heterogeneous neuronal populations within the PBN to the extended amygdala (EA) circuits which encompass the bed nucleus of the stria terminalis (BNST) and central amygdala (CeA) circuitry, as they differentially modulate aspects of behavior in response to diverse threat-like contexts necessary for survival. Here we review how the PBN→CeA and PBN→BNST pathways differentially modulate fear-like behavior, innate and conditioned, through unique changes in neurotransmission in response to stress-inducing contexts. Furthermore, we hypothesize how in specific instances the PBN→CeA and PBN→BNST circuits are redundant and in part intertwined with their respective reciprocal projections. By deconstructing the interoceptive and exteroceptive components of affect- and stress related behavioral paradigms, evidence suggests that the PBN→CeA circuit modulates innate response to physical stimuli and fear conditioning. Conversely, the PBN→BNST circuit modulates distress-like stress in unpredictable contexts. Thereby, the PBN provides a pathway for alarming interoceptive and exteroceptive stimuli to be processed and relayed to the EA to induce stress-relevant affect. Additionally, we provide a framework for future studies to detail the cell-type specific intricacies of PBN→EA circuits in mediating behavioral responses to threats, and the relevance of the PBN in drug-use as it relates to threat and negative reinforcement. This article is part of the special Issue on ‘Neurocircuitry Modulating Drug and Alcohol Abuse’.
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影响因子：
7.6
作者：
Dore, Riccardo;Iemolo, Attilio;Sabino, Valentina
通讯作者：
Sabino, Valentina
影响因子：
16.2
作者：
Delaney, Andrew J.;Crane, James W.;Sah, Pankaj
通讯作者：
Sah, Pankaj
影响因子：
3
作者：
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通讯作者：
HOFFMAN, GE
影响因子：
7.6
作者：
Ferragud, Antonio;Velazquez-Sanchez, Clara;Cottone, Pietro
通讯作者：
Cottone, Pietro
影响因子：
29
作者：
Campos CA;Bowen AJ;Schwartz MW;Palmiter RD
通讯作者：
Palmiter RD