Hypothalamic glucose-sensing mechanisms.
Hypothalamic glucose-sensing mechanisms.
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DOI：
10.1007/s00125-021-05395-6
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发表时间：
2021-05
期刊：
影响因子：
8.2
通讯作者：
Diano S
中科院分区：
文献类型：
--
作者：
Yoon NA;Diano S
慢性代谢疾病，包括糖尿病和肥胖症，已成为二十一世纪全球主要的健康威胁。维持葡萄糖稳态对于哺乳动物的生存至关重要。葡萄糖传感机制和多个效应器系统之间复杂且高度协调的相互作用对于控制血液中的葡萄糖水平至关重要。中枢神经系统（CNS）在调节葡萄糖稳态中发挥着至关重要的作用。越来越多的证据表明，下丘脑等中枢神经系统选择性区域的葡萄糖感应破坏与肥胖和 2 型糖尿病的发病机制密切相关。然而，下丘脑葡萄糖传感的潜在细胞内机制仍然难以捉摸。在这里，我们回顾了有关下丘脑葡萄糖传感机制的最新文献，并讨论了这些机制的改变对糖尿病发病机制的影响。
Chronic metabolic diseases, including diabetes and obesity, have become a major global health threat of the twenty-first century. Maintaining glucose homeostasis is essential for survival in mammals. Complex and highly coordinated interactions between glucose-sensing mechanisms and multiple effector systems are essential for controlling glucose levels in the blood. The central nervous system (CNS) plays a crucial role in regulating glucose homeostasis. Growing evidence indicates that disruption of glucose sensing in selective CNS areas, such as the hypothalamus, is closely interlinked with the pathogenesis of obesity and type 2 diabetes mellitus. However, the underlying intracellular mechanisms of glucose sensing in the hypothalamus remain elusive. Here, we review the current literature on hypothalamic glucose-sensing mechanisms and discuss the impact of alterations of these mechanisms on the pathogenesis of diabetes.
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