Response of Circulating Ghrelin Levels to Insulin Therapy in Children with Newly Diagnosed Type 1 Diabetes Mellitus
Response of Circulating Ghrelin Levels to Insulin Therapy in Children with Newly Diagnosed Type 1 Diabetes Mellitus
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新诊断 1 型糖尿病儿童循环 Ghrelin 水平对胰岛素治疗的反应
DOI：
10.1203/01.pdr.0000120679.92416.70
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发表时间：
2004
影响因子：
3.6
通讯作者：
J. Argente
中科院分区：
文献类型：
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作者：
L. Soriano;V. Barrios;A. Lechuga;J. Chowen;J. Argente
生长素释放肽主要由胃分泌，但胰腺等其他组织也合成一小部分。人类胰腺中产生生长素释放肽的新细胞类型的发现以及该器官表达 GHS-R 的发现，为理解葡萄糖代谢的控制开辟了新的视角。我们对 22 名新诊断为 1 型糖尿病的儿童进行了四个不同时间点的研究：胰岛素治疗前诊断时、胰岛素治疗 48-60 小时后、胰岛素治疗 1 个月和 4 个月后。在每个点测定生长素释放肽、瘦素、IGF-I、IGF结合蛋白(IGFBP)-1、IGFBP-2、IGFBP-3和葡萄糖的循环水平。与对照组 (867 ± 38 pg/mL) 相比，诊断时 Ghrelin 水平显着降低 (573 ± 68 pg/mL，p < 0.01)，并且在胰岛素治疗后保持降低 (d 2：595 ± 68 pg/mL；1 个月：590 ± 61 pg/mL；4 个月：538 ± 67 pg/mL)，胰岛素治疗前后没有差异。在所有研究点，生长素释放肽水平与体重指数之间均呈负相关，而生长素释放肽与葡萄糖浓度之间仅在胰岛素治疗后才观察到负相关。在任何时候都没有发现生长素释放肽和 HbA1c 之间的相关性。胰岛素治疗后发现ghrelin和IGFBP-1呈正相关，但与IGF系统其他成员或瘦素没有相关性。总之，这些数据可能表明葡萄糖浓度和生长素释放肽之间可能存在联系。因此，糖尿病儿童中持续较低的生长素释放肽水平可能表明存在针对高血糖的防御机制。
Ghrelin is secreted primarily by the stomach, although other tissues such as the pancreas synthesize a minor proportion. The discovery of a new cell type that produces ghrelin in the human pancreas and that this organ expresses GHS-R opens new perspectives in the understanding of the control of glucose metabolism. We have studied 22 children with newly diagnosed type 1 diabetes mellitus at four different points: at diagnosis before insulin therapy, after 48–60 h of insulin therapy, and after 1 and 4 mo of insulin treatment. At each point circulating levels of ghrelin, leptin, IGF-I, IGF binding protein (IGFBP)-1, IGFBP-2, IGFBP-3, and glucose were determined. Ghrelin levels were significantly decreased at diagnosis (573 ± 68 pg/mL, p < 0.01) compared with controls (867 ± 38 pg/mL) and remained decreased after insulin therapy (d 2: 595 ± 68 pg/mL; 1 mo: 590 ± 61 pg/mL; 4 mo: 538 ± 67 pg/mL) with no differences before or after insulin treatment. There was a negative correlation between ghrelin levels and body mass index at all of the study points, whereas a negative correlation between ghrelin and glucose concentrations was only observed after insulin therapy. No correlation between ghrelin and HbA1c was found at any point. A positive correlation between ghrelin and IGFBP-1 was found after insulin therapy, but no correlation with other members of the IGF system or leptin was found. In conclusion, these data could indicate a possible link between glucose concentrations and ghrelin; hence, the persisting low ghrelin levels in diabetic children may suggest a defensive mechanism against hyperglycemia.
DOI：
10.1210/jcem.87.8.8879
发表时间：
2002-08
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
M. Saad;Basem Z Bernaba;C. Hwu;Sujata D Jinagouda;Salwa Fahmi;E. Kogosov;Rima Boyadjian
通讯作者：
M. Saad;Basem Z Bernaba;C. Hwu;Sujata D Jinagouda;Salwa Fahmi;E. Kogosov;Rima Boyadjian
DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
通讯作者：
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新发 1 型糖尿病儿童胰岛素治疗前后的瘦素。
DOI：
10.1210/jcem.84.5.5653
发表时间：
1999
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Hanaki,K;Becker,DJ;Arslanian,SA
通讯作者：
Arslanian,SA