Phospholipase A2 and its molecular mechanism after spinal cord injury.
Phospholipase A2 and its molecular mechanism after spinal cord injury.
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DOI：
10.1007/s12035-010-8101-0
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发表时间：
2010-06
影响因子：
5.1
通讯作者：
Xu XM
中科院分区：
文献类型：
--
作者：
Liu NK;Xu XM
磷脂酶A2(PLA2)是一个多种多样的脂解酶家族，它能水解甘油磷脂sn-2位的酰基，生成游离脂肪酸和溶血磷脂。这些产物是生物活性二十烷基类化合物和血小板激活因子的前体，它们与许多急性和慢性神经疾病的病理状态有关。到目前为止，在哺乳动物系统中已经发现了超过27种PLA2亚型，可分为四大类：分泌型PLA2、胞浆型PLA2、钙非依赖性PLA2和血小板激活因子乙酰水解酶。在哺乳动物的脊髓中发现了PLA2的多种异构体。在生理条件下，PLA2参与多种细胞反应，包括磷脂消化和代谢、宿主防御和信号转导。然而，在病理情况下，PLA2活性增加，游离脂肪酸及其代谢物的过量产生可能导致膜完整性的丧失，炎症，氧化应激，以及随后的神经元损伤。越来越多的证据表明，PLA2在创伤性脊髓损伤后的继发性损伤过程中起着关键作用。本文概述了PLA2在脊髓中的研究现状，重点介绍了PLA2在继发性脊髓损伤中的可能作用。
Phospholipases A2 (PLA2s) are a diverse family of lipolytic enzymes which hydrolyze the acyl bond at the sn-2 position of glycerophospholipids to produce free fatty acids and lysophospholipids. These products are precursors of bioactive eicosanoids and platelet-activating factor which have been implicated in pathological states of numerous acute and chronic neurological disorders. To date, more than 27 isoforms of PLA2 have been found in the mammalian system which can be classified into four major categories: secretory PLA2, cytosolic PLA2, Ca2+-independent PLA2, and platelet-activating factor acetylhydrolases. Multiple isoforms of PLA2 are found in the mammalian spinal cord. Under physiological conditions, PLA2s are involved in diverse cellular responses, including phospholipid digestion and metabolism, host defense, and signal transduction. However, under pathological situations, increased PLA2 activity, excessive production of free fatty acids and their metabolites may lead to the loss of membrane integrity, inflammation, oxidative stress, and subsequent neuronal injury. There is emerging evidence that PLA2 plays a key role in the secondary injury process after traumatic spinal cord injury. This review outlines the current knowledge of the PLA2 in the spinal cord with an emphasis being placed on the possible roles of PLA2 in mediating the secondary SCI.
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DOI：
10.1016/0929-7855(96)00503-2
发表时间：
1996-09-01
期刊：
JOURNAL OF LIPID MEDIATORS AND CELL SIGNALLING
影响因子：
--
作者：
Bonventre, JV
通讯作者：
Bonventre, JV
影响因子：
82.9
作者：
Crowe, MJ;Bresnahan, JC;Beattie, MS
通讯作者：
Beattie, MS
影响因子：
7.4
作者：
Hamada, Y;Ikata, T;Fukuzawa, K
通讯作者：
Fukuzawa, K
影响因子：
6.2
作者：
ANDERSON, DK;DEMEDIUK, P;HORROCKS, LA
通讯作者：
HORROCKS, LA
影响因子：
4.2
作者：
DEMEDIUK, P;DALY, MP;FADEN, AI
通讯作者：
FADEN, AI