Organic thin-film transistors fabricated on resorbable biomaterial substrates.
Organic thin-film transistors fabricated on resorbable biomaterial substrates.
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DOI：
10.1002/adma.200902322
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发表时间：
2010-02-02
影响因子：
29.4
通讯作者：
Bao, Zhenan
中科院分区：
文献类型：
--
作者：
Bettinger, Christopher J.;Bao, Zhenan
利用有机材料的微电子系统提供了许多优于传统硅基系统的优点。有机电子器件具有潜在的制造优势，包括溶液加工和大规模制造，降低了成本。有机器件也可以容易地在聚合物衬底上制造，这适用于广泛的柔性电子应用，包括保形器件和显示器，并且还可能适用于卷对卷制造策略。例如，许多类型的有机器件，包括晶体管、传感器和光伏电池，已经在天然和合成的柔性聚合物上制造，包括聚（对苯二甲酸乙二醇酯）、[1-3]聚（酰亚胺）、[4]聚（醚砜）、[5]纤维素、[6，7]和丝纤蛋白。[8]由生物可降解聚合物[9]组成的各种有机聚合物系统已在许多应用中显示出实用性，包括临时医疗植入物[10，11]和可堆肥产品。[12]例如，热塑性聚酯如聚（L-丙交酯-共-乙交酯）（PLGA）是用于药物递送系统和医疗植入物的常用生物可降解聚合物，而聚（4-羟基丁酸酯）（P4 HB）通常用作一次性产品的生物可降解塑料。[13]水溶性聚合物如葡聚糖和聚（乙烯醇）已用于各种生物医学应用，包括组织工程支架[14]和环境应用。[15]有机半导体设计和合成的最新进展已经实现了可以在水合或氧化环境中稳定工作的分子[16]，包括基于噻吩[17]或芴[18]的p沟道材料和基于二萘嵌苯二酰亚胺的n沟道材料。[19]有机电子和生物可降解聚合物加工的这些伴随进步表明，存在使用生物可降解聚合物系统来开发生物可降解电子器件的潜力，该生物可降解电子器件用于生物医学或环境应用中的潜在用途。为此，我们研究了材料和制造策略，用于实现有机薄膜晶体管，使用小分子半导体与可生物降解的聚合物基板和电介质相结合。我们证明这些器械在暴露于水后性能稳定，并且由于它们几乎完全由生物可降解材料组成，因此这些器械在体外降解环境中可吸收。材料选择策略侧重于使用生物相容性和生物可降解性的材料，但也将表现出足够的电子特性和合适的器械加工能力。选择用于基底和介电层的生物材料应表现出生物学和生物学特性的独特交叉点。
Microelectronic systems utilizing organic materials afford many advantages over traditional silicon-based systems. Organic electronic devices have potential manufacturing advantages including solution processing and large scale fabrication with reduced cost. Organic devices can also be easily fabricated on polymeric substrates, which are suitable for a broad range of flexible electronics applications including conformal devices and displays, and would also be potentially suitable for roll-to-roll fabrication strategies. For example, many types of organic devices including transistors, sensors, and photovoltaic cells have been fabricated on both natural and synthetic flexible polymers including poly (ethylene terepthalate),[1-3] poly (imide),[4] poly (ether sulfone),[5] cellulose,[6, 7] and silk fibroin.[8] Various organic polymeric systems composed of biodegradable polymers [9] have demonstrated utility in many applications including temporary medical implants [10, 11] and compostable products.[12] For example, thermoplastic polyesters such as poly (L-lactide-co-glycolide)(PLGA) are commonly used biodegradable polymer for drug delivery systems and medical implants while poly (4-hydroxybutyrate)(P4HB) is commonly used as a biodegradable plastic for disposable products.[13] Water soluble polymers such as dextran and poly (vinyl alcohol) have been used for a variety of biomedical applications including tissue engineering scaffolds [14] and environmental applications.[15] Recent progress in the design and synthesis of organic semiconductors have led to the realization of molecules that can operate stably in hydrated or oxidative environments [16] including p-channel materials based on thiophenes [17] or fluorenes,[18] and n-channel materials based on perylene diimides.[19] These concomitant advancements in organic electronics and biodegradable polymers processing suggest that there is the potential for the use of biodegradable polymeric systems for the development of biodegradable electronic devices for potential use in biomedical or environmental applications. Toward this end, we investigated materials and fabrication strategies for the realization of organic thin film transistor using a small molecule semiconductor in combination with a biodegradable polymeric substrate and dielectric. We demonstrate that these devices perform stably after exposure to water and since they consist of nearly entirely biodegradable materials, these devices are resorbable in an in vitro degradation environment.A schematic of the device is shown in Figure 1. The strategy for material selection focused on utilizing materials that are biocompatible and biodegradable yet would also exhibit adequate electronic properties and suitable device processing capability. The biomaterials selected for the substrate and dielectric layer should exhibit a unique intersection of biological and
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影响因子：
56.9
作者：
Gross, RA;Kalra, B
通讯作者：
Kalra, B
影响因子：
29.4
作者：
Briseno, Alejandro L.;Tseng, Ricky J.;Bao, Zhenan
通讯作者：
Bao, Zhenan
DOI：
10.1073/pnas.0407817101
发表时间：
2004-12-28
影响因子：
11.1
作者：
Radisic, M;Park, H;Vunjak-Novakovic, G
通讯作者：
Vunjak-Novakovic, G
影响因子：
2.1
作者：
NAPOLITANO, A;PEZZELLA, A;PROTA, G
通讯作者：
PROTA, G
影响因子：
4
作者：
Jang, Y;Kim, DH;Cho, KW
通讯作者：
Cho, KW