Resistance to noise-induced gap detection impairment in FVB mice is correlated with reduced neuroinflammatory response and parvalbumin-positive neuron loss.
Resistance to noise-induced gap detection impairment in FVB mice is correlated with reduced neuroinflammatory response and parvalbumin-positive neuron loss.
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DOI：
10.1038/s41598-020-75714-1
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发表时间：
2020-11-24
影响因子：
4.6
通讯作者：
Bao S
中科院分区：
文献类型：
--
作者：
Zinsmaier AK;Wang W;Zhang L;Hossainy NN;Bao S
暴露在大噪声中会导致中枢听觉通路的神经炎性反应。噪声诱导的神经炎症与听觉处理缺陷有关，如间隙检测障碍。在这项研究中，我们研究了FVB和C57BL/6小鼠在噪声引起的GAP检测障碍方面的品系差异是否与神经炎性反应的品系差异有关。我们发现噪声诱导的肿瘤坏死因子-α在C57BL/6小鼠中的表达比在FVB小鼠中更强。在C57BL/6小鼠中观察到噪声诱导的小胶质细胞剥离，而在FVB小鼠中未观察到。此外，噪声暴露导致C57BL/6小鼠小白蛋白阳性(PV+)神经元密度降低，但FVB小鼠没有。这些结果表明，神经炎性反应和PV+神经元的丢失可能是导致噪声引起的缝隙检测损伤的品系差异的原因。
Exposure to loud noises results in neuroinflammatory responses in the central auditory pathway. Noise-induced neuroinflammation is implicated in auditory processing deficits such as impairment in gap detection. In this study, we examined whether strain differences between the FVB and C57BL/6 mice in noise-induced impairment in gap detection are correlated with strain differences in neuroinflammatory responses. We found that noise induced more robust TNF-α expression in C57BL/6 than in FVB mice. Noise-induced microglial deramification was observed in C57BL/6 mice, but not in FVB mice. Furthermore, noise exposure resulted in a reduction in parvalbumin-positive (PV+) neuron density in the C57BL/6 mice, but not in FVB mice. These results suggest that neuroinflammatory responses and loss of PV+ neurons may contribute to strain differences in noise-induced impairment in gap detection.
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影响因子：
3.3
作者：
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