The immunochemical characterization of mesangial IgA deposits.
The immunochemical characterization of mesangial IgA deposits.
复制标题
系膜 IgA 沉积物的免疫化学特征。
DOI：
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发表时间：
1983
影响因子：
6
通讯作者：
Woodroffe Aj
中科院分区：
文献类型：
--
作者：
J. Lomax‐smith;L. A. Zabrowarny;Gordon S. Howarth;A. Seymour;Woodroffe Aj
IgA肾病、过敏性紫癜(SHP)、酒精性肝硬变和系统性红斑狼疮(SLE)患者均可见IgA系膜沉积。本研究用抗A1、A2、J链和分泌成分(SC)的抗血清或单抗对上述疾病患者的系膜IgA沉积进行了研究，并检测了SC的体外结合情况。SC不存在，J链普遍存在，A2在所有组中都很少发现，但频率相同。16例酒精性肝病、3例系统性红斑狼疮、1例原发性IgA肾病、6例SHP均未检测到SC结合能力。
Mesangial deposits of IgA are found in IgA nephropathy, Schönlein-Henoch purpura (SHP) and in some patients with alcoholic cirrhosis and systemic lupus erythematosus (SLE). In this study the authors characterized the mesangial IgA deposits in patients with the above diseases using antiserums or monoclonal antibodies to A1, A2, J-chain and secretory component (SC), and examined SC binding in vitro. SC was not present, J-chain was ubiquitous, and A2 was found (with the use of monoclonal antibodies) rarely but with equal frequency in all groups. The SC binding capacity of the deposits differed between the groups and was found in 13 of 16 patients with alcoholic liver disease, 3 of 4 with SLE, 1 of 10 with primary IgA nephropathy, and none of 6 with SHP.
影响因子：
15.9
作者：
CONLEY, ME;COOPER, MD;MICHAEL, AF
通讯作者：
MICHAEL, AF