Impact of genomic damage and ageing on stem cell function.
Impact of genomic damage and ageing on stem cell function.
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DOI：
10.1038/ncb2928
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发表时间：
2014-03
影响因子：
21.3
通讯作者：
中科院分区：
文献类型：
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作者：
Impairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing. Evidence is mounting that age-dependent accumulation of DNA damage in both stem cells and cells that comprise the stem cell microenvironment are partly responsible for stem cell dysfunction with ageing. Here, we review the impact of the various types of DNA damage that accumulate with ageing on stem cell functionality, as well as the development of cancer. We discuss DNA-damage-induced cell intrinsic and extrinsic alterations that influence these processes, and review recent advances in understanding systemic adjustments to DNA damage and how they affect stem cells.
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影响因子：
30.8
作者：
Busque L;Patel JP;Figueroa ME;Vasanthakumar A;Provost S;Hamilou Z;Mollica L;Li J;Viale A;Heguy A;Hassimi M;Socci N;Bhatt PK;Gonen M;Mason CE;Melnick A;Godley LA;Brennan CW;Abdel-Wahab O;Levine RL
通讯作者：
Levine RL
影响因子：
8.8
作者：
Baker DJ;Weaver RL;van Deursen JM
通讯作者：
van Deursen JM
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
9.8
作者：
Bilousova G;Marusyk A;Porter CC;Cardiff RD;DeGregori J
通讯作者：
DeGregori J
影响因子：
11.4
作者：
Ammazzalorso, Francesca;Pirzio, Livia Maria;Pichierri, Pietro
通讯作者：
Pichierri, Pietro