Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis.
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis.
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DOI：
10.1038/ng.2413
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发表时间：
2012-11
期刊：
影响因子：
30.8
通讯作者：
Levine RL
中科院分区：
文献类型：
--
作者：
Busque L;Patel JP;Figueroa ME;Vasanthakumar A;Provost S;Hamilou Z;Mollica L;Li J;Viale A;Heguy A;Hassimi M;Socci N;Bhatt PK;Gonen M;Mason CE;Melnick A;Godley LA;Brennan CW;Abdel-Wahab O;Levine RL
衰老的特征是骨髓偏向性造血干细胞的克隆性扩增和骨髓恶性肿瘤的风险增加。通过X-失活分析证实具有克隆性造血的3名老年女性的外显子组测序鉴定了体细胞TET 2突变。复发测试发现，182名X失活偏斜患者中有10名出现TET 2突变。TET 2突变特异于无恶性血液病的克隆性造血个体，并与DNA甲基化改变相关。
Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and by an increased risk of myeloid malignancies. Exome sequencing of 3 elderly females with clonal hematopoiesis demonstrated by X-inactivation analysis identified somatic TET2 mutations. Recurrence testing found TET2 mutations in 10 out of 182 individuals with X-inactivation skewing. TET2 mutations were specific to individuals with clonal hematopoiesis without hematologic malignancies and were associated with alterations in DNA methylation.
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影响因子：
50.3
作者：
Figueroa ME;Abdel-Wahab O;Lu C;Ward PS;Patel J;Shih A;Li Y;Bhagwat N;Vasanthakumar A;Fernandez HF;Tallman MS;Sun Z;Wolniak K;Peeters JK;Liu W;Choe SE;Fantin VR;Paietta E;Löwenberg B;Licht JD;Godley LA;Delwel R;Valk PJ;Thompson CB;Levine RL;Melnick A
通讯作者：
Melnick A
影响因子：
6.5
作者：
Gale, RE;Fielding, AK;Linch, DC
通讯作者：
Linch, DC
影响因子：
50.3
作者：
Moran-Crusio K;Reavie L;Shih A;Abdel-Wahab O;Ndiaye-Lobry D;Lobry C;Figueroa ME;Vasanthakumar A;Patel J;Zhao X;Perna F;Pandey S;Madzo J;Song C;Dai Q;He C;Ibrahim S;Beran M;Zavadil J;Nimer SD;Melnick A;Godley LA;Aifantis I;Levine RL
通讯作者：
Levine RL
影响因子：
158.5
作者：
Delhommeau, Francois;Dupont, Sabrina;Bernard, Olivier A.
通讯作者：
Bernard, Olivier A.
影响因子：
11.4
作者：
Busque, L;Gilliland, DG
通讯作者：
Gilliland, DG