Oxidized DJ-1 as a possible biomarker of Parkinson's disease.
Oxidized DJ-1 as a possible biomarker of Parkinson's disease.
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DOI：
10.3164/jcbn.13-108
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发表时间：
2014-05
影响因子：
2.4
通讯作者：
Saito Y
中科院分区：
文献类型：
--
作者：
Saito Y
帕金森病是一种进行性、年龄相关的神经退行性疾病，氧化应激是其发病机制中的重要介质。DJ-1是帕金森病家族形式的致病基因，即PARK 7，并且在抗氧化防御中起重要作用以保护细胞免受氧化应激。在氧化应激下，DJ-1在位置106的半胱氨酸残基Cys-106处发生优先氧化。Cys-106在DJ-1的生物学功能中的关键作用已被证实，最近的研究表明DJ-1通过调节抗氧化防御基因的表达而作为氧化应激的传感器。已经开发了针对Cys-106-氧化DJ-1的特异性抗体，并且已经研究了帕金森病的细胞和动物模型中氧化DJ-1的产生。本文就DJ-1在抗氧化防御中的作用以及可氧化Cys-106在其功能中的重要性作一综述。识别早期帕金森病生物标志物的意义和氧化DJ-1作为帕金森病生物标志物的性质在这里进行了讨论。
Parkinson’s disease is a progressive, age-related, neurodegenerative disorder, and oxidative stress is an important mediator in its pathogenesis. DJ-1 is a causative gene of a familial form of Parkinson’s disease, namely PARK7, and plays a significant role in antioxidative defense to protect the cells from oxidative stress. DJ-1 undergoes preferential oxidation at the cysteine residue at position 106, Cys-106, under oxidative stress. The critical role of Cys-106 in the biological function of DJ-1 has been demonstrated, and recent studies indicate that DJ-1 acts as a sensor of oxidative stress by regulating the gene expression of antioxidative defense. Specific antibodies against Cys-106-oxidized DJ-1 have been developed, and the generation of oxidized DJ-1 in cellular and animal models of Parkinson’s disease has been investigated. This review focuses on the role of DJ-1 in antioxidative defense and the importance of oxidizable Cys-106 in its function. The significance of the identification of early-phase Parkinson’s disease biomarkers and the nature of oxidized DJ-1 as a biomarker for Parkinson’s disease are discussed here.
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影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ
影响因子：
4.8
作者：
Honbou, K;Suzuki, NN;Inagaki, F
通讯作者：
Inagaki, F
影响因子：
56.9
作者：
Bonifati, V;Rizzu, P;Heutink, P
通讯作者：
Heutink, P
DOI：
10.1007/bf01728311
发表时间：
1997-01-01
期刊：
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
影响因子：
--
作者：
Booij, J;Tissingh, G;vanRoyen, EA
通讯作者：
vanRoyen, EA
影响因子：
4.8
作者：
Hai-Tuong Le;Gautier, Valerie;Richarme, Gilbert
通讯作者：
Richarme, Gilbert