The treatment of metastatic germ-cell testicular tumours with bleomycin, etoposide and cis-platin (BEP).
The treatment of metastatic germ-cell testicular tumours with bleomycin, etoposide and cis-platin (BEP).
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用博来霉素、依托泊苷和顺铂 (BEP) 治疗转移性生殖细胞睾丸肿瘤。
作者：
M. Peckham;A. Barrett;Kuen Hoe Liew;A. Horwich;B. Robinson;H. Dobbs;T. Mcelwain;W. Hendry
自1979年7月至1981年12月，对43例转移性生殖细胞肿瘤(36例睾丸非精原细胞瘤和7例睾丸精原细胞瘤)进行了博莱霉素、依托泊苷和顺铂(BEP)2~6个周期的治疗。40人(93%)还活着，37人(86%)没有疾病的证据。在36例男性睾丸非精原细胞瘤患者中，30例(83.3%)在8-38个月(中位数17.0个月)时存活且无疾病。在后一组中，25/28例(89.3%)未接受过放射治疗的患者存活且无病。14例非精原细胞瘤患者有小体积转移，13例完全缓解，12/14例大块病患者也是如此。7例晚期精原细胞瘤患者全部存活且无病。结论：对于转移性生殖细胞肿瘤患者，BEP是一种耐受性好且有效的一线治疗方法。
Between July 1979 and December 1981, 43 patients with metastatic germ-cell tumours (36 testicular non-seminomas and 7 testicular seminomas) were treated with 2-6 cycles of bleomycin, etoposide and cis-platin (BEP). Forty (93%) are alive, 37 (86%) with no evidence of disease. Of 36 men with testicular non-seminoma 30 (83.3%) are alive and disease-free at 8-38 months (median 17.0 months). In the latter group 25/28 (89.3%) who had had no prior irradiation are alive and disease-free. Fourteen non-seminoma patients had small volume metastases and 13 are in complete remission, as are 12/14 patients with bulky disease. All 7 patients with advanced seminoma are alive and disease-free. It is concluded that BEP is a well tolerated and effective first line treatment for patients with metastatic germ-cell tumours.
依托泊苷挽救治疗难治性生殖细胞肿瘤：最新进展。
影响因子：
11.8
作者：
Williams,SD;Einhorn,LH
通讯作者：
Einhorn,LH