Personalized computational modeling of left atrial geometry and transmural myofiber architecture.
Personalized computational modeling of left atrial geometry and transmural myofiber architecture.
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DOI：
10.1016/j.media.2018.04.001
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发表时间：
2018-07
影响因子：
10.9
通讯作者：
Niederer SA
中科院分区：
文献类型：
--
作者：
Fastl TE;Tobon-Gomez C;Crozier A;Whitaker J;Rajani R;McCarthy KP;Sanchez-Quintana D;Ho SY;O'Neill MD;Plank G;Bishop MJ;Niederer SA
心房颤动（AF）是一种室上性快速性心律失常，其特征是完全缺乏协调的心房收缩，并与发病率和死亡率增加有关。个性化的计算建模提供了一个新的框架，整合和解释心房电生理（EP）的作用，包括潜在的解剖结构和微结构的发展和维持AF。冠状动脉计算机断层扫描血管造影数据进行分割使用基于几何的方法和平滑体素表示离散成高分辨率四面体有限元（FE）网格。为了估计复杂的左心房肌纤维结构，根据基于拉普拉斯方程的局部解的心内膜和心外膜表面上的形态学数据生成个体纤维场，并透壁内插到四面体元素。使用5种不同的纤维插值函数，通过对3名患者进行EP模拟，量化可变透壁微结构的影响。个性化的几何模型包括左心房心肌的不均匀厚度分布，随后的离散化导致高保真四面体有限元网格。用于自动合并左心房纤维结构的新算法提供了心房微结构的现实估计，并且能够定性地捕获所有重要的纤维束。一致的最大局部激活时间预测在EP模拟使用个人的透壁纤维插值函数为每个病人表明一个可以忽略不计的影响，透壁肌纤维结构对EP。已建立的建模管道为快速开发个性化模型队列提供了一个强大的框架，该模型队列考虑了详细的解剖结构和微观结构，并有助于心房EP的模拟。
Atrial fibrillation (AF) is a supraventricular tachyarrhythmia characterized by complete absence of coordinated atrial contraction and is associated with an increased morbidity and mortality. Personalized computational modeling provides a novel framework for integrating and interpreting the role of atrial electrophysiology (EP) including the underlying anatomy and microstructure in the development and sustenance of AF. Coronary computed tomography angiography data were segmented using a statistics-based approach and the smoothed voxel representations were discretized into high-resolution tetrahedral finite element (FE) meshes. To estimate the complex left atrial myofiber architecture, individual fiber fields were generated according to morphological data on the endo- and epicardial surfaces based on local solutions of Laplace’s equation and transmurally interpolated to tetrahedral elements. The influence of variable transmural microstructures was quantified through EP simulations on 3 patients using 5 different fiber interpolation functions. Personalized geometrical models included the heterogeneous thickness distribution of the left atrial myocardium and subsequent discretization led to high-fidelity tetrahedral FE meshes. The novel algorithm for automated incorporation of the left atrial fiber architecture provided a realistic estimate of the atrial microstructure and was able to qualitatively capture all important fiber bundles. Consistent maximum local activation times were predicted in EP simulations using individual transmural fiber interpolation functions for each patient suggesting a negligible effect of the transmural myofiber architecture on EP. The established modeling pipeline provides a robust framework for the rapid development of personalized model cohorts accounting for detailed anatomy and microstructure and facilitates simulations of atrial EP.
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影响因子：
3.8
作者：
Crozier A;Augustin CM;Neic A;Prassl AJ;Holler M;Fastl TE;Hennemuth A;Bredies K;Kuehne T;Bishop MJ;Niederer SA;Plank G
通讯作者：
Plank G
影响因子：
3.7
作者：
Adeniran I;MacIver DH;Garratt CJ;Ye J;Hancox JC;Zhang H
通讯作者：
Zhang H
影响因子：
10.6
作者：
Tobon-Gomez, Catalina;Geers, Arjan J.;Rhode, Kawal S.
通讯作者：
Rhode, Kawal S.
影响因子：
5
作者：
Ahn, Sung Soo;Kim, Young-Jin;Choi, Byoung Wook
通讯作者：
Choi, Byoung Wook
影响因子：
6.1
作者：
Bishop, Martin;Rajani, Ronak;Niederer, Steven
通讯作者：
Niederer, Steven