Effective purifying selection in ancient asexual oribatid mites.
Effective purifying selection in ancient asexual oribatid mites.
复制标题
DOI：
10.1038/s41467-017-01002-8
复制
发表时间：
2017-10-12
影响因子：
16.6
通讯作者：
Bast J
中科院分区：
文献类型：
--
作者：
Brandt A;Schaefer I;Glanz J;Schwander T;Maraun M;Scheu S;Bast J
从长远来看，性是有益的，因为它可以通过提高选择的有效性来防止突变的崩溃。这一观点得到了最近向无性生殖过渡的物种中有害突变积累的经验证据的支持。在此，我们研究了净化选择在数百万年前失去性并在无性繁殖中分化成不同科和种类的甲螨中的有效性。我们比较了累积有害的非同义和同义突变之间的三个无性和三个有性谱系使用转录组数据。对比研究年轻的无性谱系，我们发现的证据表明，强净化选择是更有效的，在无性相比，有性甲螨谱系。我们的研究结果表明，大种群可能维持有效的净化选择，并促进在没有性别的情况下逃避突变崩溃。因此，性别本身并不是动物谱系长期延续的先决条件。无性生殖被认为是真核生物进化的死胡同，因为有害的突变不会被有效清除。在这里，勃兰特和他的同事们表明，与有性亲属相比，古代无性的甲螨实际上减少了有害突变的积累。
Sex is beneficial in the long term because it can prevent mutational meltdown through increased effectiveness of selection. This idea is supported by empirical evidence of deleterious mutation accumulation in species with a recent transition to asexuality. Here, we study the effectiveness of purifying selection in oribatid mites which have lost sex millions of years ago and diversified into different families and species while reproducing asexually. We compare the accumulation of deleterious nonsynonymous and synonymous mutations between three asexual and three sexual lineages using transcriptome data. Contrasting studies of young asexual lineages, we find evidence for strong purifying selection that is more effective in asexual as compared to sexual oribatid mite lineages. Our results suggest that large populations likely sustain effective purifying selection and facilitate the escape of mutational meltdown in the absence of sex. Thus, sex per se is not a prerequisite for the long-term persistence of animal lineages. Asexual reproduction is thought to be an evolutionary dead end in eukaryotes because deleterious mutations will not be purged effectively. Here, Brandt and colleagues show that anciently asexual oribatid mites in fact have reduced accumulation of deleterious mutations compared to their sexual relatives.
登录
查看更多内容
影响因子：
10.7
作者：
Castresana, J
通讯作者：
Castresana, J
影响因子：
4.9
作者：
Ament-Velasquez, S. L.;Figuet, E.;Galtier, N.
通讯作者：
Galtier, N.
果蝇米兰达（Drosophila Miranda）年轻Y染色体的基因组降解。
影响因子：
12.3
作者：
Bachtrog, Doris;Hom, Emily;Wong, Karen M.;Maside, Xulio;de Jong, Pieter
通讯作者：
de Jong, Pieter
影响因子：
10.7
作者：
Henry, Lee;Schwander, Tanja;Crespi, Bernard J.
通讯作者：
Crespi, Bernard J.
影响因子：
10.7
作者：
Hollister, Jesse D.;Greiner, Stephan;Johnson, Marc T. J.
通讯作者：
Johnson, Marc T. J.