Genomic degradation of a young Y chromosome in Drosophila miranda.
Genomic degradation of a young Y chromosome in Drosophila miranda.
复制标题
果蝇米兰达（Drosophila Miranda）年轻Y染色体的基因组降解。
DOI：
10.1186/gb-2008-9-2-r30
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发表时间：
2008
期刊：
影响因子：
12.3
通讯作者：
de Jong, Pieter
中科院分区：
文献类型：
--
作者：
Bachtrog, Doris;Hom, Emily;Wong, Karen M.;Maside, Xulio;de Jong, Pieter
对果蝇（Drosophila米兰达）新近形成的新Y染色体的研究表明，新近形成的Y染色体的退化可以非常迅速地进行。Y染色体来自普通的常染色体，由于缺乏重组而退化。经过充分研究的Y染色体只剩下很少的原始基因，并且几乎没有关于其进化起源的信息。在这里，我们利用最近形成的新的Y染色体的果蝇米兰达在基因组规模上研究Y退化的过程。我们从D.米兰达，包含超过2.5 Mb的新性别连锁DNA。相对于它们的同源neo-X连接区域（1%），大部分neo-Y DNA由重复和转座元件衍生的DNA（占总DNA的20%）组成。新性别连锁BAC克隆的重叠区域包含118个基因对，其中一半在neo-Y上被假基因化。假基因在neo-Y上的进化速度明显快于功能基因，功能基因和非功能基因在neo-Y上的蛋白质进化速度都高于它们的neo-X同源物。在所调查的地区之间没有检测到退化程度的异质性。在neo-Y上的功能基因在neo-X上受到更强的进化约束，但发现基因在neo-Y上就其功能或性别偏见的表达模式而言随机退化。D.米兰达的研究表明，通过重复DNA的积累和蛋白质编码基因的退化，最近形成的Y染色体的退化可以非常迅速地进行。我们的数据支持Y染色体失活的随机模型，基因组区域之间，或基因的功能类或基因与性别偏见的表达模式之间的退化的异质性很小。
Study of the recently formed neo-Y chromosome of Drosophila miranda demonstrate that degeneration of a recently formed Y-chromosome can proceed very rapidly. Y chromosomes are derived from ordinary autosomes and degenerate because of a lack of recombination. Well-studied Y chromosomes only have few of their original genes left and contain little information about their evolutionary origin. Here, we take advantage of the recently formed neo-Y chromosome of Drosophila miranda to study the processes involved in Y degeneration on a genomic scale. We obtained sequence information from 14 homologous bacterial artificial chromosome (BAC) clones from the neo-X and neo-Y chromosome of D. miranda, encompassing over 2.5 Mb of neo-sex-linked DNA. A large fraction of neo-Y DNA is composed of repetitive and transposable-element-derived DNA (20% of total DNA) relative to their homologous neo-X linked regions (1%). The overlapping regions of the neo-sex linked BAC clones contain 118 gene pairs, half of which are pseudogenized on the neo-Y. Pseudogenes evolve significantly faster on the neo-Y than functional genes, and both functional and non-functional genes show higher rates of protein evolution on the neo-Y relative to their neo-X homologs. No heterogeneity in levels of degeneration was detected among the regions investigated. Functional genes on the neo-Y are under stronger evolutionary constraint on the neo-X, but genes were found to degenerate randomly on the neo-Y with regards to their function or sex-biased expression patterns. Patterns of genome evolution in D. miranda demonstrate that degeneration of a recently formed Y chromosome can proceed very rapidly, by both an accumulation of repetitive DNA and degeneration of protein-coding genes. Our data support a random model of Y inactivation, with little heterogeneity in degeneration among genomic regions, or between functional classes of genes or genes with sex-biased expression patterns.
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影响因子：
1.5
作者：
Steinemann, M;Steinemann, S
通讯作者：
Steinemann, S
影响因子：
64.8
作者：
Sturgill, David;Zhang, Yu;Oliver, Brian
通讯作者：
Oliver, Brian
DOI：
10.1159/000056872
发表时间：
2001-01-01
期刊：
CYTOGENETICS AND CELL GENETICS
影响因子：
--
作者：
Waters, PD;Duffy, B;Graves, JAM
通讯作者：
Graves, JAM
影响因子：
10.7
作者：
Bachtrog, D
通讯作者：
Bachtrog, D
影响因子：
30.8
作者：
Bachtrog, D
通讯作者：
Bachtrog, D