Pharmacokinetics and distribution of fluvoxamine to the brain in rats under oxidative stress
Pharmacokinetics and distribution of fluvoxamine to the brain in rats under oxidative stress
复制标题
氧化应激大鼠体内氟伏沙明的药代动力学和脑分布
DOI：
10.3109/10715762.2012.683430
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发表时间：
2012
影响因子：
3.3
通讯作者：
K. Takada
中科院分区：
文献类型：
--
作者：
Shinji Kobuchi;K. Fukushima;Yukako Ito;N. Sugioka;K. Takada
研究了氧化应激(OS)对氟伏沙明(FLV)药代动力学的影响，特别是对FLV在血浆中分布的影响。研究方案包括持续静脉滴注FLV(25.0ming/kg/μ)。稳态OS大鼠血浆Flv浓度为0.13 ± 0.0 1μg/m L，显著低于对照组(0.19 ± 0.0 1μg/m L)。此外，OS大鼠脑内的平均病毒浓度(0.51 ± 0.08μg/g)约为对照组(0.95 ± 0.11μg/g)的一半。OS组大鼠血浆和红细胞游离部分的FLV浓度均显著高于对照组。这些结果表明，在OS下，Flv的药理作用可能会减弱。
Abstract The effects of oxidative stress (OS) on the pharmacokinetics of fluvoxamine (FLV), particularly on FLV distribution in the plasma, were studied in ferric-nitrilotriacetate-induced OS rat models (OS rats). The study protocol involved a continuous FLV infusion (25.0 μg/kg/min). The resulting mean plasma FLV concentration measured in steady state OS rats was 0.13 ± 0.01 μg/mL, which was significantly lower than plasma concentrations measured in control rats (0.19 ± 0.01 μg/mL). Moreover, the mean FLV concentration in the OS rat brain (0.51 ± 0.08 μg/g) was determined to be approximately half the concentration in control rat brains (0.95 ± 0.11 μg/g). The FLV concentrations in both the unbound fraction of plasma and erythrocytes of OS rats were significantly greater than that of control rats. These results suggest the potential attenuation of FLV's pharmacological effects in patients under OS.
普罗布考脂质药理学。
DOI：
--
发表时间：
1982
期刊：
Artery
影响因子：
--
作者：
Kritchevsky,D
通讯作者：
Kritchevsky,D
氟伏沙明和氟西汀治疗重度抑郁症的比较。
影响因子：
2.9
作者：
Rapaport,M;Coccaro,E;Sheline,Y;Perse,T;Holland,P;Fabre,L;Bradford,D
通讯作者：
Bradford,D