Development and Validation of a Clinical Frailty Index for the World Trade Center General Responder Cohort.
Development and Validation of a Clinical Frailty Index for the World Trade Center General Responder Cohort.
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DOI：
10.1177/0898264321997675
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发表时间：
2021-08
影响因子：
2.8
通讯作者：
Todd AC
中科院分区：
文献类型：
--
作者：
Bello GA;Ornstein KA;Lucchini RG;Hung WW;Ko FC;Colicino E;Taioli E;Crane MA;Todd AC
开发并验证临床虚弱指数，以表征9/11世界贸易中心（WTC）袭击事件响应者的衰老。这项研究是根据6197名应答者的健康监测数据进行的。根据虚弱的累积缺陷模型，开发了临床虚弱指数WTC FI-临床。使用全因死亡率作为终点来评估所得指数的有效性。评估了其与各种队列特征的相关性。样本的平均年龄为51岁。选择了30个项目列入索引。它显示出与年龄的强相关性，以及与死亡率、9/11暴露严重程度、性别、种族、9/11前职业、教育和吸烟状况的显著调整相关性。WTC FI-临床强调了某些风险因素对9/11应答者队列中衰老的影响。它将作为一个有用的工具，用于监测和跟踪该队列中的脆弱性。
To develop and validate a clinical frailty index to characterize aging among responders to the 9/11 World Trade Center (WTC) attacks. This study was conducted on health monitoring data on a sample of 6197 responders. A clinical frailty index, WTC FI-Clinical, was developed according to the cumulative deficit model of frailty. The validity of the resulting index was assessed using all-cause mortality as an endpoint. Its association with various cohort characteristics was evaluated. The sample’s median age was 51 years. Thirty items were selected for inclusion in the index. It showed a strong correlation with age, as well as significant adjusted associations with mortality, 9/11 exposure severity, sex, race, pre-9/11 occupation, education, and smoking status. The WTC FI-Clinical highlights effects of certain risk factors on aging within the 9/11 responder cohort. It will serve as a useful instrument for monitoring and tracking frailty within this cohort.
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影响因子：
4.1
作者：
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通讯作者：
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影响因子：
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