Bioactive compounds from marine bacteria and fungi.

Bioactive compounds from marine bacteria and fungi.
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DOI:
10.1111/j.1751-7915.2010.00179.x
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发表时间:
2010-09
影响因子:
5.7
通讯作者:
Proksch P
Proksch P
中科院分区:
工程技术2区
文献类型:
--
作者:
Debbab A;Aly AH;Lin WH;Proksch P

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海洋细菌和真菌非常重要,因为新的有希望的生物活性产品的新承诺来源。具有高多样性的物种在这种条件下生存,并且到目前为止产生了引人入胜且结构上复杂的天然产物。该评论被隔离了,涵盖了最近出版的新生物活跃的天然产品(2007-09),并突出了海洋微生物的化学潜力,重点是生物活性产物及其作用机理。
Marine bacteria and fungi are of considerable importance as new promising sources of a huge number of biologically active products. Some of these marine species live in a stressful habitat, under cold, lightless and high pressure conditions. Surprisingly, a large number of species with high diversity survive under such conditions and produce fascinating and structurally complex natural products. Up till now, only a small number of microorganisms have been investigated for bioactive metabolites, yet a huge number of active substances with some of them featuring unique structural skeletons have been isolated. This review covers new biologically active natural products published recently (2007–09) and highlights the chemical potential of marine microorganisms, with focus on bioactive products as well as on their mechanisms of action.
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