Prognostic impact of plasma xanthine oxidoreductase activity in patients with heart failure with atrial fibrillation.
Prognostic impact of plasma xanthine oxidoreductase activity in patients with heart failure with atrial fibrillation.
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血浆黄嘌呤氧化还原酶活性对心力衰竭伴房颤患者的预后影响。
DOI：
10.1016/j.jjcc.2023.02.003
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Watanabe M.
中科院分区：
文献类型：
--
作者：
Watanabe K;Arimoto T;Watanabe T;Otaki Y;Murase T;Nakamura T;Kobayashi Y;Aono T;Saito Y;Koyama K;Hashimoto N;Kutsuzawa D;Kato S;Tamura H;Nishiyama S;Takahashi H;Watanabe M.
黄嘌呤氧化还原酶（Xanthine oxidoreductase，XOR）是尿酸（urine acid，UA）生成的限速酶，在活性氧（reactive oxygen species，ROS）的产生中起重要作用。据报道，ROS的过度生产，以促进心房颤动（AF）的病理生理学，然而，血浆XOR活动在心力衰竭（HF）与AF患者的预后影响是undetermined.MethodsWe测定血浆XOR活动在475 HF患者，包括窦性心律（HF-SR，n= 211），和AF（HF-AF，n= 264）。AF的类型包括阵发性（n= 128）和持续性（n= 136）AF。所有患者进行了前瞻性随访，平均时间为804 days.ResultsHF-AF患者有显着较高的血浆XOR活动和血清UA水平相比，HF-SR患者。持续性房颤患者的血浆XOR活性和血清UA水平均高于SR和阵发性房颤患者。多因素线性回归分析显示，持续性房颤与XOR活性升高独立相关。在随访期间，有79例主要不良心血管事件（MACE）。合并MACE的HF-AF患者血浆XOR活性高于无MACE者，而血清UA水平无显著差异。多因素考克斯比例分析显示，在调整混杂因素后，高XOR活性是MACE的独立危险因素。Kaplan-Meier分析显示，高XOR活性组发生MACE的风险高于低XOR活性组。预测模型显着提高了XOR活动的基础predictors.ConclusionsHF-AF患者有显着较高的血浆XOR活动相比，HF-SR患者。血浆XOR活性被证明是HF-AF患者中MACE的可靠指标。
BackgroundXanthine oxidoreductase (XOR) is a rate-limiting enzyme for uric acid (UA) production and plays an important role in generating reactive oxygen species (ROS). Overproduction of ROS is reported to contribute to the pathophysiology of atrial fibrillation (AF), however, the prognostic impact of plasma XOR activity in patients with heart failure (HF) with AF is undetermined.MethodsWe measured plasma XOR activity in 475 HF patients, including those with sinus rhythm (HF-SR,n= 211), and those with AF (HF-AF,n= 264). The type of AF included paroxysmal (n= 128) and persistent (n= 136) AF. All patients were prospectively followed up for a median period of 804 days.ResultsHF-AF patients had significantly higher plasma XOR activity and serum UA levels compared with HF-SR patients. Both plasma XOR activity and serum UA levels were higher in patients with persistent AF than in those with SR and with paroxysmal AF. Multivariate linear regression analysis showed that persistent AF was independently associated with increased XOR activity. During the follow-up period, there were 79 major adverse cardiovascular events (MACEs). HF-AF patients with MACEs had higher plasma XOR activity compared with those without MACEs, while there were no significant differences in serum UA levels. Multivariate Cox proportional analysis showed that high XOR activity was an independent risk factor for MACEs after adjustment for confounding factors. Kaplan-Meier analysis revealed that the high XOR activity group had a higher risk of MACEs than the low XOR activity group. The prediction model was significantly improved by the addition of XOR activity to the basic predictors.ConclusionsHF-AF patients had significantly higher plasma XOR activity compared with HF-SR patients. Plasma XOR activity proved to be a reliable indicator for MACEs in HF-AF patients.
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DOI：
10.1253/circj.cj-15-0138
发表时间：
2015
期刊：
Circulation journal : official journal of the Japanese Circulation Society
影响因子：
--
作者：
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通讯作者：
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影响因子：
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影响因子：
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DOI：
10.1016/j.jchromb.2016.10.033
发表时间：
2016-12-15
影响因子：
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