Oxidative stress in atrial fibrillation: an emerging role of NADPH oxidase.
Oxidative stress in atrial fibrillation: an emerging role of NADPH oxidase.
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DOI：
10.1016/j.yjmcc.2013.04.019
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发表时间：
2013-09
影响因子：
5
通讯作者：
Cai, Hua
中科院分区：
文献类型：
--
作者：
Youn, Ji-Youn;Zhang, Jun;Zhang, Yixuan;Chen, Houzao;Liu, Depei;Ping, Peipei;Weiss, James N.;Cai, Hua
房颤(房颤)是最常见的心律失常。患有房颤的患者患缺血性中风的风险高达7倍。由于目前的抗心律失常治疗效果有限，因此需要更好地了解房颤的病因及其血栓栓塞性并发症，以改善患者护理。越来越多的证据表明，氧化应激在房颤的发病机制中具有潜在的作用。过多的活性氧(ROS)的产生可能参与心脏的结构和电重构，导致纤维化和血栓形成。尤其是，基于越来越多的临床和动物研究证据，NADPH氧化酶(NOX)已成为房颤时产生ROS的潜在酶来源。事实上，NOX可以被已知的房颤上游触发因素激活，如血管紧张素II和心房拉伸。此外，他汀类药物、抗氧化剂、血管紧张素转换酶抑制剂或血管紧张素转换酶抑制剂可预防术后房颤，其中血管紧张素转换酶抑制剂/血管紧张素转换酶抑制剂和他汀类药物可减弱氮氧化物的活性。另一方面，特定的NOx亚型(S)参与房颤发病的详细分子机制以及NOx的激活在房颤发生发展中的作用程度仍有待确定。目前的综述讨论了房颤中氧化应激的原因和后果，特别关注了NOX途径的新作用。
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Patients with AF have up to seven-fold higher risk of suffering from ischemic stroke. Better understanding of etiologies of AF and its thromboembolic complications are required for improved patient care, as current anti-arrhythmic therapies have limited efficacy and off target effects. Accumulating evidence has implicated a potential role of oxidative stress in the pathogenesis of AF. Excessive production of reactive oxygen species (ROS) is likely involved in the structural and electrical remodeling of the heart, contributing to fibrosis and thrombosis. In particular, NADPH oxidase (NOX) has emerged as a potential enzymatic source for ROS production in AF based on growing evidence from clinical and animal studies. Indeed, NOX can be activated by known upstream triggers of AF such as angiotensin II and atrial stretch. In addition, treatments such as Statins, antioxidants, ACEI or AT1RB have been shown to prevent post-operative AF; among which ACEI/AT1RB and Statins can attenuate NOX activity. On the other hand, detailed molecular mechanisms by which specific NOX isoform(s) are involved in the pathogenesis of AF and the extent to which activation of NOX plays a causal role in AF development remains to be determined. The current review discusses causes and consequences of oxidative stress in AF with a special focus on the emerging role of NOX pathways.
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影响因子：
3
作者：
Bjordahl, Paul M.;Helmer, Stephen D.;Milfeld, Douglas J.
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发表时间：
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