Topical application of betahistine improves eustachian tube function in an animal model
Topical application of betahistine improves eustachian tube function in an animal model
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局部应用倍他司汀可改善动物模型中的咽鼓管功能
DOI：
10.3109/00016489.2011.607847
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发表时间：
2011
影响因子：
1.4
通讯作者：
C. Anderson
中科院分区：
文献类型：
--
作者：
B. Franz;A. Shafton;C. Anderson
结论：大鼠鼻咽局部应用倍他司汀可改善咽鼓管功能，是一种广泛应用于梅尼氏病等平衡障碍系统治疗的药物。目的：研究组胺受体激动剂倍他司汀对咽鼓管功能的影响，并检测H1和H3组胺受体的作用。方法：在麻醉大鼠中耳压力升高的情况下，测定咽鼓管功能，并在诱导吞咽过程中进行监测。将倍他司汀和其他药物局部应用于鼻咽部、大疱部和咽部，并在腹膜内给药。结果：全身应用倍他司汀对咽鼓管功能无明显影响，局部应用可显著改善咽鼓管功能。外用倍他司汀的作用不受HI受体拮抗剂美拉明的影响，而可被H3激动剂环丙沙芬模拟。
Abstract Conclusion: Betahistine dihydrochloride, a drug used widely in the systemic treatment of balance disorders such as Ménière's disease, was found to improve eustachian tube function when applied topically in the nasopharynx of rats. Objectives: The study tested the effect of betahistine, a histamine receptor agonist, on eustachian tube function and tested the involvement of H1 and H3 histamine receptors. Methods: Eustachian tube function was measured in anaesthetized rats while middle ear pressure was increased and then monitored during induced swallowing. Betahistine and other drugs were applied topically in the nasopharynx, bulla and epipharynx, and administered intraperitoneally. Results: Systemic application of betahistine hardly changed eustachian tube function, but topical application significantly improved it. The action of topical betahistine was unaffected by the HI receptor antagonist mepyramine and was mimicked by the H3 agonist, ciproxifan.
影响因子：
1.4
作者：
Nakaya, M;Takeuchi, N;Kondo, K
通讯作者：
Kondo, K
鼻粘膜组胺 H3 受体的定位和功能
DOI：
--
发表时间：
--
期刊：
Clinical and Experimental Allergy (印刷中)
影响因子：
--
作者：
Shinya Suzuki;et. al.
通讯作者：
et. al.
小鼠过敏性鼻炎中组胺 H3 受体介导的鼻过敏反应。
DOI：
--
发表时间：
2005
期刊：
Laryngoscope 115
影响因子：
--
作者：
Nakaya M;et al.
通讯作者：
et al.