Associations of tumor necrosis factor alpha receptor type 1 with kidney function decline, cardiovascular events, and mortality risk in persons with coronary artery disease: Data from the Heart and Soul Study.
Associations of tumor necrosis factor alpha receptor type 1 with kidney function decline, cardiovascular events, and mortality risk in persons with coronary artery disease: Data from the Heart and Soul Study.
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DOI：
10.1016/j.atherosclerosis.2017.05.021
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发表时间：
2017-08
期刊：
影响因子：
5.3
通讯作者：
Whooley M
中科院分区：
文献类型：
--
作者：
Park M;Maristany D;Huang D;Shlipak MG;Whooley M
1 型肿瘤坏死因子受体 (TNFR1) 与不同人群的肾脏疾病和死亡风险相关。肾功能是否介导死亡风险尚不清楚。我们评估了患有稳定型缺血性心脏病的退伍军人中 TNFR1 水平与肾功能、心血管事件和死亡率的关系。 TNFR1 是通过 Heart and Soul 研究中的基线血清样本进行测量的；升高的水平由最高四分位数定义（Q4，> 3.4 ng/mL）。我们评估了高 TNFR1 与基线估计肾小球滤过率 (eGFR) 和尿白蛋白与肌酐比 (ACR) 的关联，以及与 eGFR 纵向变化（快速丢失）的关联，以及在中位随访时间 8.9 年中与心肌梗死 (MI)、心力衰竭住院 (HF) 和死亡率的关联。协变量包括人口统计数据和合并症。在 985 名进行 TNFR1 测量的参与者中，TNFR1 中位数为 2.33 ng/ml (IQR 1.8-3.1)。相对于 Q1，Q4 的 eGFR < 60 ml/min/1.73 m2 的风险更高（RR 11.71 [95% CI 5.46, 25.11]）； ACR ≥ 30 毫克/克（2.44 [1.15，5.19]）；肾功能迅速丧失（2.10 [1.12, 3.92]）。尽管人口调整后 TNFR1 Q4 与 MI、HF 和死亡率相关，但在完全调整模型中没有相关性（分别为 1.04 [0.44, 2.49]；1.02 [0.48, 2.15]；1.42 [0.88, 2.28]）。调整后，TNFR1 水平与肾功能下降纵向相关，但与 MI、HF 或死亡风险无关。肾脏疾病可能会介导与 TNFR1 相关的 MI、HF 和死亡风险。
Tumor necrosis factor receptor type 1 (TNFR1) is associated with kidney disease and mortality risk in various populations. Whether or not kidney function mediates mortality risk is unknown. We evaluated associations of TNFR1 levels with measures of kidney function, cardiovascular events, and mortality in a population of veterans with stable ischemic heart disease. TNFR1 was measured from baseline serum samples in the Heart and Soul Study; elevated levels were defined by the highest quartile (Q4, > 3.4 ng/mL). We evaluated associations of high TNFR1 with baseline estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (ACR) and with longitudinal changes in eGFR (rapid loss), as well as with incident myocardial infarction (MI), heart failure hospitalizations (HF), and mortality over a median follow-up time of 8.9 years. Covariates included demographics and comorbid conditions. Among 985 participants who had TNFR1 measurements, median TNFR1 was 2.33 ng/ml (IQR 1.8–3.1). Relative to Q1, Q4 had higher risk of eGFR < 60 ml/min/1.73 m2 (RR 11.71 [95% CI 5.46, 25.11]); ACR ≥ 30 mg/g (2.44 [1.15, 5.19]); and rapid loss in kidney function (2.10 [1.12, 3.92]). Although TNFR1 Q4 was associated with MI, HF, and mortality after demographic adjustment, there were no associations in fully-adjusted models (1.04 [0.44, 2.49]; 1.02 [0.48, 2.15]; 1.42 [0.88, 2.28] respectively). Levels of TNFR1 are associated longitudinally with kidney function decline but not with MI, HF or mortality risk after adjustment. Kidney disease may mediate the risk of MI, HF, and mortality associated with TNFR1.
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影响因子：
19.6
作者：
通讯作者：
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肿瘤坏死因子受体1和2与2型糖尿病的早期肾小球病变有关。
影响因子：
19.6
作者：
Pavkov ME;Weil EJ;Fufaa GD;Nelson RG;Lemley KV;Knowler WC;Niewczas MA;Krolewski AS
通讯作者：
Krolewski AS
DOI：
10.1056/nejmoa1114248
发表时间：
2012-07-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Inker LA;Schmid CH;Tighiouart H;Eckfeldt JH;Feldman HI;Greene T;Kusek JW;Manzi J;Van Lente F;Zhang YL;Coresh J;Levey AS;CKD-EPI Investigators
通讯作者：
CKD-EPI Investigators
影响因子：
13.6
作者：
Niewczas, Monika A.;Gohda, Tomohito;Krolewski, Andrzej S.
通讯作者：
Krolewski, Andrzej S.
影响因子：
37.8
作者：
Valgimigli, M;Ceconi, C;Ferrari, R
通讯作者：
Ferrari, R