Astrocyte elevated gene-1 (AEG-1) and the A(E)Ging HIV/AIDS-HAND.
Astrocyte elevated gene-1 (AEG-1) and the A(E)Ging HIV/AIDS-HAND.
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DOI：
10.1016/j.pneurobio.2016.03.006
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发表时间：
2017-10
影响因子：
6.7
通讯作者：
Ghorpade A
中科院分区：
文献类型：
--
作者：
Vartak-Sharma N;Nooka S;Ghorpade A
最近对人类免疫缺陷病毒(HIV)-1诱导的星形胶质细胞基因表达变化的分析发现了一个多功能致癌基因，星形胶质细胞升高基因-1 （AEG-1）。我们之前的研究表明，AEG-1调节星形胶质细胞的增殖、迁移和炎症，这些都是衰老和中枢神经系统损伤的标志。此外，AEG-1参与神经退行性疾病，如亨廷顿氏病和偏头痛，以及它在老年大脑中的诱导作用，表明它在调节中枢神经系统整体稳态和衰老方面的作用似乎是合理的。因此，研究AEG-1在衰老相关认知能力下降中的作用具有重要意义。在这项研究中，我们破译了癌症、衰老和hiv -1相关神经认知障碍的共同机制联系，这些联系可能有助于aeg -1对星形胶质细胞反应和功能的调节。尽管AEG-1能被HIV-1病毒粒子结合并被HIV-1、肿瘤坏死因子-α和白细胞介素-1β诱导，但AEG-1在星形胶质细胞驱动的HIV-1神经发病机制中的具体作用尚不完全明确。我们认为AEG-1在涉及线粒体、内质网和核仁的多种细胞应激反应中起核心作用。因此，进一步研究基于AEG-1的细胞和分子调控是很重要的，以便成功地开发出更好的治疗方法，以AEG-1为靶点，对抗癌症、HIV-1和衰老。
Recent attempts to analyze human immunodeficiency virus (HIV)-1-induced gene expression changes in astrocytes uncovered a multifunctional oncogene, astrocyte elevated gene-1 (AEG-1). Our previous studies revealed that AEG-1 regulates reactive astrocytes proliferation, migration and inflammation, all hallmarks of aging and CNS injury. Moreover, the involvement of AEG-1 in neurodegenerative disorders, such as Huntington’s disease and migraine, and its induction in the aged brain suggest a plausible role in regulating overall CNS homeostasis and aging. Therefore, it is important to investigate AEG-1 specifically in aging-associated cognitive decline. In this study, we decipher the common mechanistic links in cancer, aging and HIV-1-associated neurocognitive disorders that likely contribute to AEG-1-based regulation of astrocyte responses and function. Despite AEG-1 incorporation into HIV-1 virions and its induction by HIV-1, tumor necrosis factor-α and interleukin-1β, the specific role(s) of AEG-1 in astrocyte-driven HIV-1 neuropathogenesis are incompletely defined. We propose that AEG-1 plays a central role in a multitude of cellular stress responses involving mitochondria, endoplasmic reticulum and the nucleolus. It is thus important to further investigate AEG-1-based cellular and molecular regulation in order to successfully develop better therapeutic approaches that target AEG-1 to combat cancer, HIV-1 and aging.
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影响因子：
4.8
作者：
Barreto, George;Santos-Galindo, Maria;Garcia-Segura, Luis M.
通讯作者：
Garcia-Segura, Luis M.
T细胞的免疫突触诱导体内和体外脑星形胶质细胞极化：一种新型的星形胶质细胞反应机制对细胞损伤。
影响因子：
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作者：
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影响因子：
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作者：
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DOI：
10.1016/j.bbrc.2008.04.084
发表时间：
2008-06-27
影响因子：
3.1
作者：
Ash, S. C.;Yang, D. Q.;Britt, D. E.
通讯作者：
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影响因子：
3.2
作者：
Akay C;Cooper M;Odeleye A;Jensen BK;White MG;Vassoler F;Gannon PJ;Mankowski J;Dorsey JL;Buch AM;Cross SA;Cook DR;Peña MM;Andersen ES;Christofidou-Solomidou M;Lindl KA;Zink MC;Clements J;Pierce RC;Kolson DL;Jordan-Sciutto KL
通讯作者：
Jordan-Sciutto KL