Patterned variation in murine MHC promoters
Patterned variation in murine MHC promoters
复制标题
小鼠 MHC 启动子的模式变异
DOI：
10.1073/pnas.152329999
复制
发表时间：
2002
影响因子：
11.1
通讯作者：
J. Roes
中科院分区：
文献类型：
--
作者：
N. Mitchison;J. Roes
To compare variation in regulatory and coding DNA, promoter sequences have been obtained from wild-derived mice and laboratory rats. The sequences are from the proximal promoter of the H2Aa, H2Ab, H2Eb, and H2K genes of 24 wild-derived inbred strains and a sample of the corresponding exon 2 sequences and of the RT1.Ba gene of six strains of laboratory rat. They reveal a high level of variation in the mouse MHC class II promoters (H2A and H2E), a low level in MHC class I (H2K), and none in the rat. The variation is pronounced in and around the cAMP response element, a major binding site for modulating promoter activity in response to external stimulation. This finding, together with the different levels of variation in MHC classes I and II, is suggestive of natural selection. However, selection operating via the MHC coding sequences must also contribute, as indicated by the minimal variation in both the MHC class II promoter and coding sequences of the rat. Furthermore CIITA (trans-activator of class II) of the mouse has been reported to have minimal variation in its promoter and none in its coding sequence. Taken together these data suggest that the regulatory and coding sequences undergo coselection. Each of the mouse class II promoters has a pattern of variation that appears to be basically dimorphic, with further variation added by recombination/mutation. The dimorphic allelic lineages are in marginally detectable linkage disequilibrium with the exon 2 sequences, particularly in H2Aa, thus lending further support to the coevolution hypothesis.
DOI：
10.1073/pnas.88.2.453
发表时间：
1991-01
影响因子：
11.1
作者：
Jin-Xiong She;Stefen Boehme;Tie Wang;F. Bonhomme;Edward K. Wakeland
通讯作者：
Jin-Xiong She;Stefen Boehme;Tie Wang;F. Bonhomme;Edward K. Wakeland
影响因子：
32.4
作者：
Moreno, CS;Beresford, GW;Boss, JM
通讯作者：
Boss, JM
影响因子：
39.3
作者：
Humphries, SE;Luong, LA;Miller, GJ
通讯作者：
Miller, GJ