Cardiometabolic Phenotypic Differences in Male Offspring Born to Obese Preeclamptic-Like BPH/5 Mice.
Cardiometabolic Phenotypic Differences in Male Offspring Born to Obese Preeclamptic-Like BPH/5 Mice.
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DOI：
10.3389/fped.2021.636143
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发表时间：
2021
影响因子：
2.6
通讯作者：
Sones JL
中科院分区：
文献类型：
--
作者：
Beckers KF;Gomes VCL;Crissman KJR;Adams DM;Liu CC;Del Piero F;Butler SD;Sones JL
子痫前期（PE）是一种妊娠高血压疾病，全世界约有10%的妇女发生。虽然它对母亲和婴儿都有生命威胁，但唯一有效的治疗方法是分娩胎盘和胎儿，这通常是早产。母亲肥胖是PE的一个危险因素，两者对后代的影响长期存在，成年后心脏代谢疾病的发病率增加。肥胖的BPH/5小鼠自发地表现出妊娠期体重过度增加和妊娠后期高血压，与PE女性相似，同时胎儿生长受限，雌性后代代偿性生长加速。我们假设BPH/5雄性后代将表现出与BPH/5雌性相似的心血管和代谢表型。如前所述，与年龄匹配的成年女性对照组相比，自由喂养的雌性雌性BPH/5体重过重，伴有嗜食，皮下、肾周和性腺周围白色脂肪组织（WAT）增加，心脏肥大。在这项研究中，BPH/5成年雄性小鼠的体重和食物摄入量与年龄匹配的对照组小鼠相似，但皮下和肾周炎症性WAT增加，并有心血管疾病的迹象：左心室肥厚和高血压。因此，成年雄性BPH/5不能完全复制雌性BPH/5小鼠的心脏代谢谱。未来的研究有必要了解BPH/5雄性和雌性小鼠随着年龄的增长所观察到的差异。综上所述，在BPH/5小鼠模型中，PE对雄性和雌性后代的影响具有跨代效应。母亲的肥胖环境可能在PE妊娠结局中发挥作用，包括随着年龄增长的后代健康。
Preeclampsia (PE) is a hypertensive disorder of pregnancy occurring in approximately 10% of women worldwide. While it is life threatening to both the mother and baby, the only effective treatment is delivery of the placenta and fetus, which is often preterm. Maternal obesity is a risk factor for PE, and the effects of both on offspring are long standing with increased incidence of cardiometabolic disease in adulthood. Obese BPH/5 mice spontaneously exhibit excessive gestational weight gain and late-gestational hypertension, similar to women with PE, along with fetal growth restriction and accelerated compensatory growth in female offspring. We hypothesized that BPH/5 male offspring will demonstrate cardiovascular and metabolic phenotypes similar to BPH/5 females. As previously described, BPH/5 females born to ad libitum-fed dams are overweight with hyperphagia and increased subcutaneous, peri-renal, and peri-gonadal white adipose tissue (WAT) and cardiomegaly compared to age-matched adult female controls. In this study, BPH/5 adult male mice have similar body weights and food intake compared to age-matched control mice but have increased inflammatory subcutaneous and peri-renal WAT and signs of cardiovascular disease: left ventricular hypertrophy and hypertension. Therefore, adult male BPH/5 do not completely phenocopy the cardiometabolic profile of female BPH/5 mice. Future investigations are necessary to understand the differences observed in BPH/5 male and female mice as they age. In conclusion, the impact of fetal programming due to PE has a transgenerational effect on both male and female offspring in the BPH/5 mouse model. The maternal obesogenic environment may play a role in PE pregnancy outcomes, including offspring health as they age.
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DOI：
10.1152/ajpregu.00049.2014
发表时间：
2014-07-01
期刊：
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子：
--
作者：
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影响因子：
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