Inflamed leukocyte-mimetic nanoparticles for molecular imaging of inflammation.
Inflamed leukocyte-mimetic nanoparticles for molecular imaging of inflammation.
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DOI：
10.1016/j.biomaterials.2011.06.030
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发表时间：
2011-10
期刊：
影响因子：
14
通讯作者：
Jin, Moonsoo M.
中科院分区：
文献类型：
--
作者：
Chen, Xiaoyue;Wong, Richard;Khalidov, Ildar;Wang, Andrew Y.;Leelawattanachai, Jeerapond;Wang, Yi;Jin, Moonsoo M.
Dysregulated host inflammatory response causes many diseases, including cardiovascular and neurodegenerative diseases, cancer, and sepsis. Sensitive detection of the site of inflammation will, therefore, produce a wide-ranging impact on disease diagnosis and treatment. We hypothesized that nanoprobes designed to mimic the molecular interactions occurring between inflamed leukocytes and endothelium may possess selectivity toward diverse host inflammatory responses. To incorporate inflammation-sensitive molecular interactions, superparamagnetic iron oxide nanoparticles were conjugated with integrin lymphocyte function-associated antigen (LFA)-1 I domain, engineered to mimic activated leukocytes in physiology. Whole body optical and magnetic resonance imaging in vivo revealed that leukocyte-mimetic nanoparticles localized preferentially to the vasculature within and in the invasive front of the tumor, as well as to the site of acute inflammation. This study explored in vivo detection of tumor-associated vasculature with systemically injected inflammation-specific nanoparticles, presenting a possibility of tumor detection by inflamed tumor microenvironment.
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影响因子：
14
作者：
Nahrendorf, Matthias;Keliher, Edmund;Panizzi, Peter;Zhang, Hanwen;Hembrador, Sheena;Figueiredo, Jose-Luiz;Aikawa, Elena;Kelly, Kimberly;Libby, Peter;Weissleder, Ralph
通讯作者：
Weissleder, Ralph
动脉粥样硬化的炎症。
DOI：
10.1161/atvbaha.108.179705
发表时间：
2012-09
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Libby P
通讯作者：
Libby P
影响因子：
56.9
作者：
Dubertret, B;Skourides, P;Libchaber, A
通讯作者：
Libchaber, A
影响因子：
14
作者：
Park, Spencer;Kang, Sungkwon;Jin, Moonsoo M.
通讯作者：
Jin, Moonsoo M.
影响因子：
4.5
作者：
Cianchi, F.;Cuzzocrea, S.;Masini, E.
通讯作者：
Masini, E.