Interactive effects of inbreeding and endocrine disruption on reproduction in a model laboratory fish.
Interactive effects of inbreeding and endocrine disruption on reproduction in a model laboratory fish.
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DOI：
10.1111/j.1752-4571.2012.00288.x
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发表时间：
2013-02
影响因子：
4.1
通讯作者：
Tyler CR
中科院分区：
文献类型：
--
作者：
Bickley LK;Brown AR;Hosken DJ;Hamilton PB;Le Page G;Paull GC;Owen SF;Tyler CR
近亲繁殖抑郁症在压力大的环境中会更严重。然而，近亲繁殖在多大程度上影响了种群对环境压力因素的脆弱性，如化学品暴露，仍未得到解决。在这里，我们报告了近亲繁殖和暴露于内分泌干扰化学物质（杀菌剂氯霉唑）对斑马鱼（Danio rerio）的综合影响。我们表明，虽然近亲繁殖会对生殖性状产生负面影响，但并不是所有性状都受到同样的影响。近亲繁殖衰退通常只有在鱼类受到化学物质暴露的额外压力时才会变得明显。近交暴露鱼的胚胎活力显著降低，近交雄鱼在与近交个体直接竞争时，有繁殖后代较少的趋势。血浆11-酮睾酮（一种关键的男性性激素）水平显示出明显的近交抑制，而添加杀菌剂不影响这种抑制。相比之下，近交或接触氯霉唑对产蛋量没有影响。总的来说，我们的数据提供了证据，表明压力可能会放大近亲繁殖对关键生殖特征的影响，尤其是那些与男性健康相关的特征。在考虑暴露于化学污染物对野生种群适应性的影响时，这可能具有重要的意义。
Inbreeding depression is expected to be more severe in stressful environments. However, the extent to which inbreeding affects the vulnerability of populations to environmental stressors, such as chemical exposure, remains unresolved. Here we report on the combined impacts of inbreeding and exposure to an endocrine disrupting chemical (the fungicide clotrimazole) on zebrafish (Danio rerio). We show that whilst inbreeding can negatively affect reproductive traits, not all traits are affected equally. Inbreeding depression frequently only became apparent when fish were additionally stressed by chemical exposure. Embryo viability was significantly reduced in inbred exposed fish and there was a tendency for inbred males to sire fewer offspring when in direct competition with outbred individuals. Levels of plasma 11-ketotestosterone, a key male sex hormone, showed substantial inbreeding depression that was unaffected by addition of the fungicide. In contrast, there was no effect of inbreeding or clotrimazole exposure on egg production. Overall, our data provide evidence that stress may amplify the effects of inbreeding on key reproductive traits, particularly those associated with male fitness. This may have important implications when considering the consequences of exposure to chemical pollutants on the fitness of wild populations.
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影响因子：
1.3
作者：
Frommen, Joachim G.;Luz, Corinna;Bakker, Theo C. M.
通讯作者：
Bakker, Theo C. M.
影响因子：
2.1
作者：
Bijlsma, R;Bundgaard, J;Van Putten, WF
通讯作者：
Van Putten, WF
DOI：
10.1098/rspb.2010.0514
发表时间：
2010-11-22
影响因子：
4.7
作者：
Michalczyk, Lukasz;Martin, Oliver Y.;Gage, Matthew J. G.
通讯作者：
Gage, Matthew J. G.
影响因子：
2.7
作者：
Coe, T. S.;Hamilton, P. B.;Tyler, C. R.
通讯作者：
Tyler, C. R.
影响因子：
10.4
作者：
Harris CA;Hamilton PB;Runnalls TJ;Vinciotti V;Henshaw A;Hodgson D;Coe TS;Jobling S;Tyler CR;Sumpter JP
通讯作者：
Sumpter JP