Liquid acrylate-endcapped biodegradable poly(epsilon-caprolactone-co-trimethylene carbonate). I. Preparation and visible light-induced photocuring characteristics.
Liquid acrylate-endcapped biodegradable poly(epsilon-caprolactone-co-trimethylene carbonate). I. Preparation and visible light-induced photocuring characteristics.
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液体丙烯酸酯封端的可生物降解聚（ε-己内酯-共-三亚甲基碳酸酯）。
DOI：
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
T. Matsuda
中科院分区：
文献类型：
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作者：
M. Mizutani;T. Matsuda
以多官能团羟基物质（二、三、四官能醇和聚乙二醇（PEG）及其四支链衍生物）为引发剂，通过ε-己内酯（CL）和三亚甲基碳酸酯（TMC）开环共聚制备光固化液态可生物降解共聚物，随后在其羟基末端用丙烯酰氯封端。这些多官能团、粘性液体共聚物（分子量；约2 x 10(3) 至7 x 10(3) g/mol）在樟脑醌作为引发剂的存在下通过可见光照射转化为交联固体。这些共聚物的光固化速率因所用共聚物的较高官能度和较低分子量而得到提高。光固化速率取决于还原剂(甲基丙烯酸2-二甲基氨基乙酯)的量。浸入磷酸盐缓冲溶液（pH 7.4）后，水解优先发生在表面，但光固化的 PEG 基共聚物除外，光固化的 PEG 基共聚物通过表面侵蚀和本体降解比低分子量醇基共聚物降解得更快。通过在填充有液体共聚物的模具中对全身进行光照射来制备圆柱形光固化结构，作为可生物降解的生物医学装置的形状制造的例子。
Photocurable liquid biodegradable copolymers were prepared by ring-opening copolymerization of epsilon-caprolactone (CL) and trimethylene carbonate (TMC) in the presence of a multifunctional hydroxyl group-bearing substance (di-, tri-, and tetra-functional alcohol and poly(ethylene glycol) (PEG) and its four-branched derivative) as an initiator and subsequent endcapping with acryloyl chloride at their hydroxyl terminals. These multifunctional, viscous liquid copolymers (molecular weights; approximately 2 x 10(3) to 7 x 10(3) g/mol) were converted to crosslinked solids by visible-light irradiation in the presence of camphorquinone as an initiator. The photocuring rate of these copolymers was enhanced by both higher functionality and lower molecule weight of the copolymers used. The photocuring rate depended on the amount of reducing agent (methacrylic acid 2-dimethylaminoethyl ester). Upon immersion in a phosphate buffer solution (pH 7.4), hydrolysis occurred preferentially on the surface except for photocured PEG-based copolymers that were degraded faster via both surface erosion and bulk degradation than low molecular weight alcohols-based copolymers. Cylindrical photocured constructs prepared by photoirradiation to the whole body in a mold filled with the liquid copolymer was demonstrated as an example of shape fabrication of biodegradable biomedical devices.
DOI：
10.1073/pnas.96.6.3104
发表时间：
1999-03-16
影响因子：
11.1
作者：
Elisseeff, J;Anseth, K;Langer, R
通讯作者：
Langer, R