Molecular mechanisms of mechanotransduction in integrin-mediated cell-matrix adhesion.
Molecular mechanisms of mechanotransduction in integrin-mediated cell-matrix adhesion.
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DOI：
10.1016/j.yexcr.2016.10.001
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发表时间：
2016-11-15
影响因子：
3.7
通讯作者：
Zhu, Cheng
中科院分区：
文献类型：
--
作者：
Li, Zhenhai;Lee, Hyunjung;Zhu, Cheng
细胞基质粘附复合物是将细胞外基质 (ECM) 连接到细胞骨架的多蛋白结构。它们通过双向传感和传递机械和生化刺激，对细胞运动和功能至关重要。已鉴定出几种类型的细胞-基质粘附，它们共享许多关键分子成分，例如整合素和肌动蛋白-整合素连接子。从单细胞到单分子水平，从免疫细胞到神经元细胞，都观察到了 ECM 分子和肌动蛋白细胞骨架之间的机械化学耦合。然而，整合素介导的机械转导的力调节背后的机制仍然需要阐明。在这篇综述文章中，我们重点关注整合素介导的粘附，并讨论细胞基质粘附和关键适配器分子的力调节、三种不同的力依赖性行为以及力调节中机械化学耦合的分子机制。
Cell-matrix adhesion complexes are multi-protein structures linking the extracellular matrix (ECM) to the cytoskeleton. They are essential to both cell motility and function by bidirectionally sensing and transmitting mechanical and biochemical stimulations. Several types of cell-matrix adhesions have been identified and they share many key molecular components, such as integrins and actin-integrin linkers. Mechanochemical coupling between ECM molecules and the actin cytoskeleton has been observed from the single cell to the single molecule level and from immune cells to neuronal cells. However, the mechanisms underlying force regulation of integrin-mediated mechanotransduction still need to be elucidated. In this review article, we focus on integrin-mediated adhesions and discuss force regulation of cell-matrix adhesions and key adaptor molecules, three different force-dependent behaviors, and molecular mechanisms for mechanochemical coupling in force regulation.
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