Driver genes in non-small cell lung cancer: Characteristics, detection methods, and targeted therapies.
Driver genes in non-small cell lung cancer: Characteristics, detection methods, and targeted therapies.
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非小细胞肺癌的驱动基因：特征、检测方法和靶向治疗
DOI：
10.18632/oncotarget.17016
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发表时间：
2017-08-22
期刊：
影响因子：
--
通讯作者：
Zhang HQ
中科院分区：
文献类型：
--
作者：
Zhu QG;Zhang SM;Ding XX;He B;Zhang HQ
肺癌是世界上最常见的癌症相关死亡原因之一。非小细胞肺癌（non-small cell lung cancer，NSCLC）是肺癌的主要类型，约占肺癌的75%。在过去的几年里，我们对NSCLC分子生物学的全面了解迅速丰富，这促进了NSCLC驱动基因的发现和FDA批准的靶向治疗。当然，基于驱动基因的靶向治疗为晚期非小细胞肺癌提供了更准确的选择，提高了患者的生存率。现就非小细胞肺癌驱动基因的特点、检测方法、靶向治疗的应用及面临的挑战作一综述。
Lung cancer is one of the most common causes of cancer-related death in the world. The large number of lung cancer cases is non-small cell lung cancer (NSCLC), which approximately accounting for 75% of lung cancer. Over the past years, our comprehensive knowledge about the molecular biology of NSCLC has been rapidly enriching, which has promoted the discovery of driver genes in NSCLC and directed FDA-approved targeted therapies. Of course, the targeted therapies based on driver genes provide a more exact option for advanced non-small cell lung cancer, improving the survival rate of patients. Now, we will review the landscape of driver genes in NSCLC including the characteristics, detection methods, the application of target therapy and challenges.
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DOI：
10.1158/1078-0432.ccr-14-2683
发表时间：
2015-08-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Drilon A;Wang L;Arcila ME;Balasubramanian S;Greenbowe JR;Ross JS;Stephens P;Lipson D;Miller VA;Kris MG;Ladanyi M;Rizvi NA
通讯作者：
Rizvi NA
影响因子：
56.9
作者：
COUSSENS, L;YANGFENG, TL;ULLRICH, A
通讯作者：
ULLRICH, A
影响因子：
4
作者：
Degola, F.;Berni, E.;Restivo, F. M.
通讯作者：
Restivo, F. M.
影响因子：
20.4
作者：
Goldstraw, Peter;Chansky, Kari;Bolejack, Vanessa
通讯作者：
Bolejack, Vanessa
影响因子：
28.2
作者：
Agrawal N;Jiao Y;Bettegowda C;Hutfless SM;Wang Y;David S;Cheng Y;Twaddell WS;Latt NL;Shin EJ;Wang LD;Wang L;Yang W;Velculescu VE;Vogelstein B;Papadopoulos N;Kinzler KW;Meltzer SJ
通讯作者：
Meltzer SJ