Advances in Pancreatic Islet Transplantation Sites for the Treatment of Diabetes.
Advances in Pancreatic Islet Transplantation Sites for the Treatment of Diabetes.
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DOI：
10.3389/fendo.2021.732431
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发表时间：
2021
影响因子：
5.2
通讯作者：
Yoshihara E
中科院分区：
文献类型：
--
作者：
Cayabyab F;Nih LR;Yoshihara E
糖尿病是一种复杂的疾病，全世界有超过4亿人受到影响。1型糖尿病(T1D)患者需要终生注射胰岛素和持续监测血糖，这是一种巨大的临床和经济负担，迫切需要一种医学解决方案。胰岛移植在治疗T1D方面有很大的应用前景，但难以调节移植后免疫反应以避免同种异体和自身免疫移植物排斥反应是胰岛移植领域的一个瓶颈。细胞替代策略已经在肝脏、肌肉内、大网膜和皮下部位进行，并在动物模型和人类患者中进行。然而，需要更合适的移植部位和方法来提高胰岛移植物的存活率，才能成功地将这些研究转化为临床相关治疗。本文就目前胰岛移植领域、方法和部位的研究进展作一综述，其中包括干细胞来源的功能性人胰岛。我们还讨论了免疫细胞、血管形成、细胞外基质和营养供应对胰岛移植物存活的贡献。利用新兴技术开发新的移植部位，以提高胰岛移植物的存活率和简化免疫调节，将极大地有助于胰岛细胞治疗在糖尿病治疗中的未来成功。
Diabetes is a complex disease that affects over 400 million people worldwide. The life-long insulin injections and continuous blood glucose monitoring required in type 1 diabetes (T1D) represent a tremendous clinical and economic burdens that urges the need for a medical solution. Pancreatic islet transplantation holds great promise in the treatment of T1D; however, the difficulty in regulating post-transplantation immune reactions to avoid both allogenic and autoimmune graft rejection represent a bottleneck in the field of islet transplantation. Cell replacement strategies have been performed in hepatic, intramuscular, omentum, and subcutaneous sites, and have been performed in both animal models and human patients. However more optimal transplantation sites and methods of improving islet graft survival are needed to successfully translate these studies to a clinical relevant therapy. In this review, we summarize the current progress in the field as well as methods and sites of islet transplantation, including stem cell-derived functional human islets. We also discuss the contribution of immune cells, vessel formation, extracellular matrix, and nutritional supply on islet graft survival. Developing new transplantation sites with emerging technologies to improve islet graft survival and simplify immune regulation will greatly benefit the future success of islet cell therapy in the treatment of diabetes.
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影响因子：
29
作者：
Cefalu WT;Rodgers GP
通讯作者：
Rodgers GP
影响因子：
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作者：
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