Ipsilateral and Contralateral Interactions in Spinal Locomotor Circuits Mediated by V1 Neurons: Insights from Computational Modeling.
Ipsilateral and Contralateral Interactions in Spinal Locomotor Circuits Mediated by V1 Neurons: Insights from Computational Modeling.
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DOI：
10.3390/ijms23105541
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发表时间：
2022-05-16
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
我们描述和分析了哺乳动物脊髓神经回路的计算模型，负责产生和塑造运动样振荡。该模型代表了脊髓神经元的相互作用群体，包括在先前的一系列实验研究中被遗传鉴定和表征的神经元。在这里，我们特别关注同侧投射的V1中间神经元，它们在脊髓运动回路中的可能作用，以及它们参与运动振荡的产生。这些神经元的拟议连接及其参与脊髓中不同的神经元通路允许该模型再现这些神经元在不同实验条件下的光遗传学操作的结果。我们建议存在两个不同的V1中间神经元介导不同的同侧和对侧脊髓内的相互作用。该模型提出了多个实验数据的解释，光遗传沉默和激活V1中间神经元的影响，在不同的实验条件下，在完整的脊髓和hemicord的运动振荡的频率。我们的模拟为哺乳动物脊髓运动回路的组织提供了重要的见解。
We describe and analyze a computational model of neural circuits in the mammalian spinal cord responsible for generating and shaping locomotor-like oscillations. The model represents interacting populations of spinal neurons, including the neurons that were genetically identified and characterized in a series of previous experimental studies. Here, we specifically focus on the ipsilaterally projecting V1 interneurons, their possible role in the spinal locomotor circuitry, and their involvement in the generation of locomotor oscillations. The proposed connections of these neurons and their involvement in different neuronal pathways in the spinal cord allow the model to reproduce the results of optogenetic manipulations of these neurons under different experimental conditions. We suggest the existence of two distinct populations of V1 interneurons mediating different ipsilateral and contralateral interactions within the spinal cord. The model proposes explanations for multiple experimental data concerning the effects of optogenetic silencing and activation of V1 interneurons on the frequency of locomotor oscillations in the intact cord and hemicord under different experimental conditions. Our simulations provide an important insight into the organization of locomotor circuitry in the mammalian spinal cord.
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