Chemosensory loss: functional consequences of the world trade center disaster.
Chemosensory loss: functional consequences of the world trade center disaster.
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DOI：
10.1289/ehp.1001924
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发表时间：
2010-09
影响因子：
10.4
通讯作者：
Moline J
中科院分区：
文献类型：
--
作者：
Dalton PH;Opiekun RE;Gould M;McDermott R;Wilson T;Maute C;Ozdener MH;Zhao K;Emmett E;Lees PS;Herbert R;Moline J
参与世界贸易中心（WTC）现场救援、恢复、拆除和清理的人员暴露在空气中烟雾、灰尘、燃烧气体、酸雾和金属烟雾的复杂混合物中。这种暴露有可能损害鼻化学感觉（嗅觉和三叉神经）功能。本研究的目的是评估这些个体中化学感觉功能障碍和鼻腔炎症的患病率。我们研究了102个人谁工作或志愿者在2001年9月11日（9/11）期间和之后的几天和几周在世贸中心网站和一个对照组，没有世贸中心接触匹配的每个参与者的年龄，性别和职称。参与者在一次会议上全面评估了化学感觉功能和鼻腔炎症。从自我报告的问卷中获得个体暴露史。相对于对照组，WTC暴露组中嗅觉和三叉神经敏感性丧失的患病率显著更高[气味和刺激阈值的患病率比（95%置信区间）分别为1.96（1.2-3.3）和3.28（2.7-3.9）]。然而，在世贸中心的响应者中，被9/11倒塌的尘埃云困住的人表现出最严重的三叉神经损失。鼻灌洗样本的分析支持WTC暴露队列中慢性鼻部炎症的临床结果。当检测空气中气味或刺激物的能力是一个关键的安全因素时，暴露于WTC的组在暴露2年多后出现明显的化学感觉障碍的患病率引起了这些人的担忧。这一结果凸显了对接触急性高水平或慢性空气污染物的个人进行化学感觉评估的必要性。
Individuals involved in rescue, recovery, demolition, and cleanup at the World Trade Center (WTC) site were exposed to a complex mixture of airborne smoke, dust, combustion gases, acid mists, and metal fumes. Such exposures have the potential to impair nasal chemosensory (olfactory and trigeminal) function. The goal of this study was to evaluate the prevalence of chemosensory dysfunction and nasal inflammation among these individuals. We studied 102 individuals who worked or volunteered at the WTC site in the days and weeks during and after 11 September 2001 (9/11) and a comparison group with no WTC exposure matched to each participant on age, sex, and job title. Participants were comprehensively evaluated for chemosensory function and nasal inflammation in a single session. Individual exposure history was obtained from self-reported questionnaires. The prevalence of olfactory and trigeminal nerve sensitivity loss was significantly greater in the WTC-exposed group relative to the comparison group [prevalence ratios (95% confidence intervals) = 1.96 (1.2–3.3) and 3.28 (2.7–3.9) for odor and irritation thresholds, respectively]. Among the WTC responders, however, individuals caught in the dust cloud from the collapse on 9/11 exhibited the most profound trigeminal loss. Analysis of the nasal lavage samples supported the clinical findings of chronic nasal inflammation among the WTC-exposed cohort. The prevalence of significant chemosensory impairment in the WTC-exposed group more than 2 years after their exposure raises concerns for these individuals when the ability to detect airborne odors or irritants is a critical safety factor. This outcome highlights the need for chemosensory evaluations among individuals with exposure to acute high or chronic levels of airborne pollutants.
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影响因子：
3.5
作者：
Dalton, P;Cowart, B;Emmett, E
通讯作者：
Emmett, E
影响因子：
10.4
作者：
Herbert, Robin;Moline, Jacqueline;Levin, Stephen M.
通讯作者：
Levin, Stephen M.
影响因子：
6.3
作者：
AHLSTROM, R;BERGLUND, B;WENNBERG, A
通讯作者：
WENNBERG, A
影响因子：
5.2
作者：
Kleinman, LI;Daum, PH;Rudolph, J
通讯作者：
Rudolph, J
DOI：
10.1152/physiol.00026.2008
发表时间：
2008-12
期刊：
Physiology (Bethesda, Md.)
影响因子：
--
作者：
Bessac BF;Jordt SE
通讯作者：
Jordt SE