Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2011-2014.
Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2011-2014.
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DOI：
10.1017/ice.2016.174
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发表时间：
2016-11
影响因子：
4.5
通讯作者：
Sievert DM
中科院分区：
文献类型：
--
作者：
Weiner LM;Webb AK;Limbago B;Dudeck MA;Patel J;Kallen AJ;Edwards JR;Sievert DM
描述2011-2014年发生的医疗保健相关感染（HAIs）的抗菌素耐药性模式，并向疾病控制和预防中心的国家医疗保健安全网络报告。分析了中央静脉相关血流感染、导尿管相关尿路感染、呼吸机相关肺炎和手术部位感染的数据。这些HAIs报告来自急性护理医院、长期急性护理医院和住院康复机构。按年份和HAI类型计算经检测对选定抗菌素耐药（或不敏感）的病原体的汇总平均比例。总体而言，4,515家医院报告2011-2014年至少发生了1起HAI。向国家卫生保健安全网报告的365,490例卫生保健感染中有408,151例病原体，其中大多数来自床位超过200张的急症护理医院。15个病原体组占报告病原体的87%；最常见的包括大肠杆菌（15%）、金黄色葡萄球菌（12%）、克雷伯氏菌（8%）和凝固酶阴性葡萄球菌（8%）。总的来说，与手术部位感染相比，器械相关HAIs中具有常见耐药表型的分离株比例更高。虽然大多数表型的耐药百分比与早期报告相似，但注意到大肠杆菌病原体耐药百分比的幅度增加，特别是与氟喹诺酮类药物耐药有关。本报告代表了精选HAIs和表型中抗菌素耐药性的国家摘要。2009-2010年，常见病原体的分布和一些耐药模式似乎发生了变化，这突出表明需要持续、仔细地监测各种HAI类型的这些数据。
To describe antimicrobial resistance patterns for healthcare-associated infections (HAIs) that occurred in 2011–2014 and were reported to the Centers for Disease Control and Prevention’s National Healthcare Safety Network. Data from central line–associated bloodstream infections, catheter-associated urinary tract infections, ventilator-associated pneumonias, and surgical site infections were analyzed. These HAIs were reported from acute care hospitals, long-term acute care hospitals, and inpatient rehabilitation facilities. Pooled mean proportions of pathogens that tested resistant (or nonsusceptible) to selected antimicrobials were calculated by year and HAI type. Overall, 4,515 hospitals reported that at least 1 HAI occurred in 2011–2014. There were 408,151 pathogens from 365,490 HAIs reported to the National Healthcare Safety Network, most of which were reported from acute care hospitals with greater than 200 beds. Fifteen pathogen groups accounted for 87% of reported pathogens; the most common included Escherichia coli (15%), Staphylococcus aureus (12%), Klebsiella species (8%), and coagulase-negative staphylococci (8%). In general, the proportion of isolates with common resistance phenotypes was higher among device-associated HAIs compared with surgical site infections. Although the percent resistance for most phenotypes was similar to earlier reports, an increase in the magnitude of the resistance percentages among E. coli pathogens was noted, especially related to fluoroquinolone resistance. This report represents a national summary of antimicrobial resistance among select HAIs and phenotypes. The distribution of frequent pathogens and some resistance patterns appear to have changed from 2009–2010, highlighting the need for continual, careful monitoring of these data across the spectrum of HAI types.
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影响因子：
11.8
作者：
Chea, Nora;Bulens, Sandra N.;Kallen, Alexander J.
通讯作者：
Kallen, Alexander J.
影响因子：
14.2
作者：
Magiorakos, A. -P.;Srinivasan, A.;Monnet, D. L.
通讯作者：
Monnet, D. L.
影响因子：
4.5
作者：
Sievert, Dawn M.;Ricks, Philip;Fridkin, Scott
通讯作者：
Fridkin, Scott
影响因子：
4.9
作者：
Dudeck, Margaret A.;Edwards, Jonathan R.;Sievert, Dawn M.
通讯作者：
Sievert, Dawn M.
DOI：
10.1111/ajt.13893
发表时间：
2016-03-11
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Weiner, Lindsey M;Fridkin, Scott K;McDonald, L Clifford
通讯作者：
McDonald, L Clifford