Antennal lobe representations are optimized when olfactory stimuli are periodically structured to simulate natural wing beat effects.
Antennal lobe representations are optimized when olfactory stimuli are periodically structured to simulate natural wing beat effects.
复制标题
DOI：
10.3389/fncel.2014.00159
复制
发表时间：
2014
影响因子：
5.3
通讯作者：
Daly KC
中科院分区：
文献类型：
--
作者：
Houot B;Burkland R;Tripathy S;Daly KC
动物利用行为积极地对各种感官领域的环境进行采样。这些行为将感觉体验离散成独特的时空时刻，最大限度地减少感觉适应，并增强感知。在嗅觉中，嗅觉、触角轻弹和拍打翅膀等行为都会周期性地暴露嗅觉上皮。在哺乳动物中，人们认为嗅觉增强了神经表征；然而，昆虫拍打翅膀对表征的影响仍不清楚。为了确定在模拟拍翅效应时，触角叶(AL)产生气味依赖表征的情况，我们使用细胞外方法记录了蛾AL的神经单位和局部场电位(LFP)。我们记录了对气味的反应，这些反应表现为持续时间较长的刺激，或者周期性地表现为20和25赫兹的脉冲串，旨在模拟气味引导飞行期间天线周围翅膀拍打的振荡效应。使用光谱分析，我们表明，所有记录的单元中有大约25%能够缠绕到“脉冲刺激”；这包括脉冲空白，这引起了最强的整体缠绕。对脉冲串刺激的夹带强度取决于气味的分子特征、气味浓度和脉冲串持续时间。此外，在气味刺激期间，显示脉冲跟踪反应的单位与LFP高度锁相，这表明单位-LFP的相位关系是由刺激驱动的。最后，一项基于欧几里得距离的种群向量分析建立了AL气味表征更稳健，峰值更快，并且当气味以自然的翅膀节拍频率呈现时，与长期持续刺激相反，没有表现出适应性。这些结果提出了一种优化嗅觉表征的一般策略，该策略通过在AL水平上整合机械感觉和嗅觉线索来利用翅膀跳动的自然节律性。
Animals use behaviors to actively sample the environment across a broad spectrum of sensory domains. These behaviors discretize the sensory experience into unique spatiotemporal moments, minimize sensory adaptation, and enhance perception. In olfaction, behaviors such as sniffing, antennal flicking, and wing beating all act to periodically expose olfactory epithelium. In mammals, it is thought that sniffing enhances neural representations; however, the effects of insect wing beating on representations remain unknown. To determine how well the antennal lobe (AL) produces odor dependent representations when wing beating effects are simulated, we used extracellular methods to record neural units and local field potentials (LFPs) from moth AL. We recorded responses to odors presented as prolonged continuous stimuli or periodically as 20 and 25 Hz pulse trains designed to simulate the oscillating effects of wing beating around the antennae during odor guided flight. Using spectral analyses, we show that ~25% of all recorded units were able to entrain to “pulsed stimuli”; this includes pulsed blanks, which elicited the strongest overall entrainment. The strength of entrainment to pulse train stimuli was dependent on molecular features of the odorants, odor concentration, and pulse train duration. Moreover, units showing pulse tracking responses were highly phase locked to LFPs during odor stimulation, indicating that unit-LFP phase relationships are stimulus-driven. Finally, a Euclidean distance-based population vector analysis established that AL odor representations are more robust, peak more quickly, and do not show adaptation when odors were presented at the natural wing beat frequency as opposed to prolonged continuous stimulation. These results suggest a general strategy for optimizing olfactory representations, which exploits the natural rhythmicity of wing beating by integrating mechanosensory and olfactory cues at the level of the AL.
登录
查看更多内容
影响因子：
2.5
作者：
Daly, KC;Wright, GA;Smith, BH
通讯作者：
Smith, BH
DOI：
10.1073/pnas.0401902101
发表时间：
2004-07-13
影响因子：
11.1
作者：
Daly, KC;Christensen, TA;Hildebrand, JG
通讯作者：
Hildebrand, JG
影响因子：
2.2
作者：
Daly, KC;Durtschi, ML;Smith, BH
通讯作者：
Smith, BH
影响因子：
1.5
作者：
BAKER, TC;WILLIS, MA;PHELAN, PL
通讯作者：
PHELAN, PL
影响因子：
2.2
作者：
Bau, J;Justus, KA;Cardé, RT
通讯作者：
Cardé, RT