HIV testing and burden of HIV infection in black cancer patients in Johannesburg, South Africa: a cross-sectional study.
HIV testing and burden of HIV infection in black cancer patients in Johannesburg, South Africa: a cross-sectional study.
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DOI：
10.1186/s12885-015-1171-7
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发表时间：
2015-03-18
期刊：
影响因子：
3.8
通讯作者：
Urban MI
中科院分区：
文献类型：
--
作者：
Sengayi M;Babb C;Egger M;Urban MI
艾滋病毒感染是已知的癌症风险因素，但人们对艾滋病毒检测模式和癌症患者艾滋病毒感染的负担知之甚少。我们进行了一项横断面分析，以确定先前HIV检测的预测因素，并量化南非约翰内斯堡黑人癌症患者的HIV负担。约翰内斯堡癌症病例对照研究（JCCCS）招募了在约翰内斯堡公立转诊医院接受肿瘤学和放射治疗的新诊断的黑人癌症患者。从2004年11月到2009年12月，所有参加JCCCS的成年癌症患者都被纳入分析，并接受了以前的艾滋病毒检测。使用单一ELISA检测对患者进行独立的HIV-1检测。计算了既往艾滋病毒检测、艾滋病毒感染和未确诊艾滋病毒感染的患病率。多元逻辑回归模型拟合，以确定与先前的艾滋病毒检测相关的因素。共有5436例癌症患者接受了HIV检测，其中1833例[33.7%（95% CI=32.5-35.0）]为HIV阳性。四分之三的患者（4092名患者）曾接受过艾滋病毒检测。未确诊的HIV感染的总患病率为11.5%（10.7-12.4），其中1833例HIV检测阳性的患者中有34%（32.0-36.3）不知道自己感染了HIV。>49岁的男性[OR 0.49（0.39-0.63）]和居住在农村地区的男性[OR 0.61（0.39-0.97）]以前接受艾滋病毒检测的可能性较小。至少受过中等教育的男性[OR 1.79（1.11-2.90）]和近年来接受采访的男性[OR 4.13（2.62 - 6.52）]可能有过既往检测。>49岁的女性[OR 0.33（0.27-0.41）]以前接受过艾滋病毒检测的可能性较小。在女性中，有孩子<5岁[OR 2.59（2.04-3.29）]，使用激素避孕药[OR 1.33（1.09-1.62）]，至少接受过中学教育[OR：2.08（1.45-2.97）]和最近一年的面试[OR 6.04（4.45-8.2）]与既往HIV检测独立相关。在对约翰内斯堡新诊断的黑人癌症患者进行的一项研究中，超过三分之一的艾滋病毒阳性患者不知道自己的艾滋病毒状况。在南非，黑人癌症患者应该成为选择退出艾滋病毒检测的目标。本文的在线版本（doi：10.1186/s12885-015-1171-7）包含补充材料，可供授权用户使用。
HIV infection is a known risk factor for cancer but little is known about HIV testing patterns and the burden of HIV infection in cancer patients. We did a cross-sectional analysis to identify predictors of prior HIV testing and to quantify the burden of HIV in black cancer patients in Johannesburg, South Africa. The Johannesburg Cancer Case–control Study (JCCCS) recruits newly-diagnosed black cancer patients attending public referral hospitals for oncology and radiation therapy in Johannesburg . All adult cancer patients enrolled into the JCCCS from November 2004 to December 2009 and interviewed on previous HIV testing were included in the analysis. Patients were independently tested for HIV-1 using a single ELISA test . The prevalence of prior HIV testing, of HIV infection and of undiagnosed HIV infection was calculated. Multivariate logistic regression models were fitted to identify factors associated with prior HIV testing. A total of 5436 cancer patients were tested for HIV of whom 1833[33.7% (95% CI=32.5-35.0)] were HIV-positive. Three-quarters of patients (4092 patients) had ever been tested for HIV. The total prevalence of undiagnosed HIV infection was 11.5% (10.7-12.4) with 34% (32.0–36.3) of the 1833 patients who tested HIV-positive unaware of their infection. Men >49 years [OR 0.49(0.39–0.63)] and those residing in rural areas [OR 0.61(0.39–0.97)] were less likely to have been previously tested for HIV. Men with at least a secondary education [OR 1.79(1.11–2.90)] and those interviewed in recent years [OR 4.13(2.62 – 6.52)] were likely to have prior testing. Women >49 years [OR 0.33(0.27–0.41)] were less likely to have been previously tested for HIV. In women, having children <5 years [OR 2.59(2.04–3.29)], hormonal contraceptive use [OR 1.33(1.09–1.62)], having at least a secondary education [OR:2.08(1.45–2.97)] and recent year of interview [OR 6.04(4.45–8.2)] were independently associated with previous HIV testing. In a study of newly diagnosed black cancer patients in Johannesburg, over a third of HIV-positive patients were unaware of their HIV status. In South Africa black cancer patients should be targeted for opt-out HIV testing. The online version of this article (doi:10.1186/s12885-015-1171-7) contains supplementary material, which is available to authorized users.
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影响因子：
4.2
作者：
Sanchez TH;Kelley CF;Rosenberg E;Luisi N;O'Hara B;Lambert R;Coleman R;Frew P;Salazar LF;Tao S;Clarke W;Del Rio C;Sullivan PS
通讯作者：
Sullivan PS
影响因子：
3.4
作者：
Nagaiah G;Stotler C;Orem J;Mwanda WO;Remick SC
通讯作者：
Remick SC
DOI：
10.1111/j.1365-3156.2011.02937.x
发表时间：
2012-08
期刊：
Tropical medicine & international health : TM & IH
影响因子：
--
作者：
Cremin I;Cauchemez S;Garnett GP;Gregson S
通讯作者：
Gregson S
影响因子：
120.7
作者：
Chiao, Elizabeth Y.;Dezube, Bruce J.;Pantanowitz, Liron
通讯作者：
Pantanowitz, Liron
影响因子：
4.5
作者：
Peltzer K;Matseke G;Mzolo T;Majaja M
通讯作者：
Majaja M