Decrease of Choline Acetyltransferase Activity of Rat Cortex Capillaries with Aging
Decrease of Choline Acetyltransferase Activity of Rat Cortex Capillaries with Aging
复制标题
大鼠皮质毛细血管胆碱乙酰转移酶活性随衰老的降低
DOI：
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发表时间：
1985
影响因子：
4.7
通讯作者：
J. L. González
中科院分区：
文献类型：
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作者：
F. Santos;J. L. González
摘要：对3月龄、12月龄、18月龄和24月龄大鼠大脑皮质毛细血管胆碱乙酰转移酶(ChAT)活性进行了测定。12个月时酶活性最高(55±0.3pmol·mg−1蛋白·分钟−1；平均扫描电子显微镜)，24个月时降至最低(34±3.1pmol·mg−1蛋白·分钟−1)。在同一组大鼠的皮质匀浆和突触体组分中，也发现酶活性下降得不那么明显。随着年龄的增长，大脑毛细血管ChAT的丢失可能与这种情况下皮质胆碱能缺陷的普遍现象有关。
Abstract: Choline acetyltransferase (ChAT) activity was estimated in brain cortex capillaries isolated from 3‐, 12‐, 18‐, and 24‐month‐old rats. Maximum enzymatic activity was found at 12 months (55 ± 0.3 pmol · mg−1 protein · min−1; mean ± SEM) and then it decreased to reach a minimum at 24 months (34 ± 3.1 pmol · mg−1 protein · min−1). A less marked decrease of enzymatic activity was also found in cortex homogenate and in a synaptosomal fraction obtained from the same groups of rats. Loss of ChAT of brain capillaries with aging could be related to a general phenomenon of cortical cholinergic deficit in that condition.
影响因子：
56.9
作者：
COYLE, JT;PRICE, DL;DELONG, MR
通讯作者：
DELONG, MR