Therapeutic effect of intratumoral injections of dendritic cells for locally recurrent gastric cancer: a case report.
Therapeutic effect of intratumoral injections of dendritic cells for locally recurrent gastric cancer: a case report.
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DOI：
10.1186/1477-7819-12-390
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发表时间：
2014-12-19
影响因子：
3.2
通讯作者：
DC-vaccine study group at the Japan Society of Innovative Cell Therapy (J-SICT)
中科院分区：
文献类型：
--
作者：
Kobayashi M;Sakabe T;Chiba A;Nakajima A;Okamoto M;Shimodaira S;Yonemitsu Y;Shibamoto Y;Suzuki N;Nagaya M;DC-vaccine study group at the Japan Society of Innovative Cell Therapy (J-SICT)
一位有胃癌及肺气肿病史的80岁男性于1997年因胃癌行远端胃切除术。2010年内镜检查发现吻合口侧凹陷型病变，诊断为印戒腺癌。手术治疗被考虑，但由于阻塞性和限制性呼吸事件被拒绝。化疗因不良事件终止。通过内镜给瘤内注射树突状细胞（dc）靶向Wilms tumor 1 （WT1）和mucin 1， cell-surface associated （MUC1）的合成肽。肿瘤样本的免疫组化分析显示WT1和MUC1阳性。2010年11月至2011年4月7次DC治疗1个月后，未见明显可疑病变，活检结果正常。病人病情已经缓解了30个月。该患者不能行内镜下粘膜剥离或手术，瘤内注射DCs显示出治疗效果。
An 80-year-old man with a history of gastric cancer and pulmonary emphysema underwent a distal gastrectomy for gastric cancer in 1997. In 2010, an endoscopic examination revealed a depressed-type lesion at the oral side of the anastomosis, which was diagnosed as signet-ring adenocarcinoma. Surgical management was considered, but was rejected because of obstructive and restrictive respiratory events. Chemotherapy was terminated because of adverse events. Endoscopy was used to administer intratumoral injections of dendritic cells (DCs) targeting synthesized peptides of Wilms tumor 1 (WT1) and mucin 1, cell-surface associated (MUC1). An immunohistochemical analysis of the tumor samples indicated positivity for WT1 and MUC1. One month after seven cycles of DC had been administered (between November 2010 and April 2011), no suspicious lesions were evident, and his biopsy results were normal. The patient has been in remission for 30 months. Intratumoral injections of DCs showed therapeutic effects in this patient, who could not undergo endoscopic submucosal dissection or surgery.
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