Ethnicity, gender, and age effects on adrenoceptors and physiological responses to emotional stress.

Ethnicity, gender, and age effects on adrenoceptors and physiological responses to emotional stress.
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种族、性别和年龄对肾上腺素受体和对情绪压力的生理反应的影响。

DOI:
10.1111/j.1469-8986.00161.x
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发表时间:
2004
期刊:
影响因子:
3.7
通讯作者:
Zimmerman,Eugene
Zimmerman,Eugene
中科院分区:
心理学3区
文献类型:
--
作者:
Suarez,EdwardC;Saab,PatriceG;Llabre,MariaM;Kuhn,CynthiaM;Zimmerman,Eugene

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我们研究了种族、性别和年龄对愤怒回忆访谈的心血管和儿茶酚胺反应以及外周血单个核细胞上β2肾上腺素能受体密度和功能的独特和联合影响。参与者为179名不吸烟、血压正常的男性和女性,年龄在18-49岁之间。在愤怒回忆访谈中,所有受试者都表现出相似的血压升高。然而,黑人男性的心率增加幅度最小,外周血管扩张也有所减弱。黑人女性和白人在心率和外周血管扩张方面表现出类似的增加。在黑人男性中,年龄越大,去甲肾上腺素越容易引起愤怒回忆。黑人男性在整个方案中也表现出更高的肾上腺素水平,对125I-吲哚的解离常数更高,以及β-2受体密度随年龄的增加而增加。相对于白人和黑人女性,黑人男性对负面情绪的唤醒导致交感神经系统活动模式,这可能有助于解释这一人群高血压患病率较高的原因。
We examined the unique and joint effects of ethnicity, gender, and age on cardiovascular and catecholamine responses to the anger recall interview, and β2‐adrenergic receptor density and function on peripheral blood mononuclear cells. Participants were 179 nonsmoking, normotensive men and women aged 18–49 years. All subjects showed similar blood pressure increases during the anger recall interview. Black men, however, showed the smallest increases in heart rate in conjunction with an attenuated peripheral vasodilatation. Black women and Whites showed similar increases in heart rate and peripheral vasodilatation. Increasing age was associated with greater norepinephrine increases to anger recall in Black males. Black men also exhibited higher epinephrine levels throughout the protocol, higher dissociation constant to125I‐pindolol, and age‐dependent increases in β2‐receptor density. Relative to Whites and Black females, arousal of negative affect in Black males led to a pattern of sympathetic nervous system activity that may help explain the higher prevalence of hypertension in this population.
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