Single-unit activity in the medial prefrontal cortex during immediate and delayed extinction of fear in rats.
Single-unit activity in the medial prefrontal cortex during immediate and delayed extinction of fear in rats.
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DOI：
10.1371/journal.pone.0011971
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发表时间：
2010-08-05
期刊：
影响因子：
3.7
通讯作者：
Maren S
中科院分区：
文献类型：
--
作者：
Chang CH;Berke JD;Maren S
在恐惧条件反射后几分钟进行灭绝试验，只会产生短期的恐惧抑制，第二天就会完全恢复。由于灭绝已被报道，以增加CS诱发的尖峰放电和自发爆裂的边缘下（IL）划分内侧前额叶皮层（mPFC），我们探讨了这种立即灭绝赤字的可能性，改变mPFC功能。在听觉恐惧条件反射后10分钟（立即）或24小时（延迟）进行的消退过程中，在大鼠中同时记录IL神经元和mPFC边缘前（PrL）分裂的单个单位。与以前的报道相比，IL神经元表现出CS-诱发的反应早期在灭绝训练在立即和延迟的条件下，这些反应的幅度下降的过程中灭绝训练。在保留测试期间，CS诱发的IL放电在未能获得消退的动物中显著更大。自发爆发期间的灭绝和测试会议也是不同的立即和延迟组。在消退或保留试验期间，PrL活性无组间差异。IL中自发和CS诱发的神经元活动的改变可能导致立即消退缺陷。
Delivering extinction trials minutes after fear conditioning yields only a short-term fear suppression that fully recovers the following day. Because extinction has been reported to increase CS-evoked spike firing and spontaneous bursting in the infralimbic (IL) division of the medial prefrontal cortex (mPFC), we explored the possibility that this immediate extinction deficit is related to altered mPFC function. Single-units were simultaneously recorded in rats from neurons in IL and the prelimbic (PrL) division of the mPFC during an extinction session conducted 10 minutes (immediate) or 24 hours (delayed) after auditory fear conditioning. In contrast to previous reports, IL neurons exhibited CS-evoked responses early in extinction training in both immediate and delayed conditions and these responses decreased in magnitude over the course of extinction training. During the retention test, CS-evoked firing in IL was significantly greater in animals that failed to acquire extinction. Spontaneous bursting during the extinction and test sessions was also different in the immediate and delayed groups. There were no group differences in PrL activity during extinction or retention testing. Alterations in both spontaneous and CS-evoked neuronal activity in the IL may contribute to the immediate extinction deficit.
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