Hippocampal neurogenesis and the brain repair response to brief stereotaxic insertion of a microneedle.
Hippocampal neurogenesis and the brain repair response to brief stereotaxic insertion of a microneedle.
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DOI：
10.1155/2013/205878
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发表时间：
2013
影响因子：
4.3
通讯作者：
Sanchez-Ramos J
中科院分区：
文献类型：
--
作者：
Song S;Song S;Cao C;Lin X;Li K;Sava V;Sanchez-Ramos J
We tested the hypothesis that transient microinjury to the brain elicits cellular and humoral responses that stimulate hippocampal neurogenesis. Brief stereotaxic insertion and removal of a microneedle into the right hippocampus resulted in (a) significantly increased expression of granulocyte-colony stimulating factor (G-CSF), the chemokine MIP-1a, and the proinflammatory cytokine IL12p40; (b) pronounced activation of microglia and astrocytes; and (c) increase in hippocampal neurogenesis. This study describes immediate and early humoral and cellular mechanisms of the brain's response to microinjury that will be useful for the investigation of potential neuroprotective and deleterious effects of deep brain stimulation in various neuropsychiatric disorders.
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Bronstein JM;Tagliati M;Alterman RL;Lozano AM;Volkmann J;Stefani A;Horak FB;Okun MS;Foote KD;Krack P;Pahwa R;Henderson JM;Hariz MI;Bakay RA;Rezai A;Marks WJ Jr;Moro E;Vitek JL;Weaver FM;Gross RE;DeLong MR
通讯作者：
DeLong MR
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Ostergaard, K.
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通讯作者：
Tresco, Patrick A.
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9.9
作者：
Burbaud, P;Vital, A;Bioulac, B
通讯作者：
Bioulac, B