In vitro models for human malaria: targeting the liver stage.
In vitro models for human malaria: targeting the liver stage.
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DOI：
10.1016/j.pt.2022.05.014
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发表时间：
2022-09
影响因子：
9.6
通讯作者：
Roth, Alison
中科院分区：
文献类型：
--
作者：
Valenciano, Ana Lisa;Gomez-Lorenzo, Maria G.;Vega-Rodriguez, Joel;Adams, John H.;Roth, Alison
The Plasmodium liver stage represents a vulnerable therapeutic target to prevent disease progression as the parasite resides in the liver before clinical representation caused by intraerythrocytic development. However, most antimalarial drugs target the blood stage of the parasite’s life cycle and the few that target the liver stage are lethal to patients with a glucose-6-phosphate dehydrogenase deficiency. Furthermore, implementation of in vitro liver models to study and develop novel therapeutics against the liver stage of human Plasmodium species remain challenging. In this review, we focus on the progression of in vitro liver models developed for human Plasmodium spp. parasites, provide a brief review on important assay requirements and lastly present recommendations to improve models to enhance the discovery process of novel preclinical therapeutics.
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影响因子：
1.3
作者：
COLLINS, WE;WARREN, M;NGUYENDINH, P
通讯作者：
NGUYENDINH, P
影响因子：
5.4
作者：
Adams JH;Mueller I
通讯作者：
Mueller I
DOI：
10.4269/ajtmh.15-0007
发表时间：
2015-09
期刊：
The American journal of tropical medicine and hygiene
影响因子：
--
作者：
Cui L;Mharakurwa S;Ndiaye D;Rathod PK;Rosenthal PJ
通讯作者：
Rosenthal PJ
影响因子：
3.7
作者：
Dumoulin PC;Trop SA;Ma J;Zhang H;Sherman MA;Levitskaya J
通讯作者：
Levitskaya J
影响因子：
82.9
作者：
Dembele, Laurent;Franetich, Jean-Francois;Mazier, Dominique
通讯作者：
Mazier, Dominique