Cortical anatomical variations, gene expression profiles, and clinical phenotypes in patients with schizophrenia.
Cortical anatomical variations, gene expression profiles, and clinical phenotypes in patients with schizophrenia.
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DOI：
10.1016/j.nicl.2023.103451
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发表时间：
2023
影响因子：
4.2
通讯作者：
Lv, Luxian
中科院分区：
文献类型：
--
作者：
Han, Yong;Yang, Yongfeng;Zhou, Zhilu;Jin, Xueyan;Shi, Han;Shao, Minglong;Song, Meng;Su, Xi;Wang, Qi;Liu, Qing;Li, Wenqiang;Lv, Luxian
本研究旨在探讨精神分裂症患者大脑皮层解剖变异与基因表达及临床表型的关系。精神分裂症患者大脑皮层的解剖特征表现出广泛而一致的变异，这与基因的转录组谱相关，尤其是皮层厚度和局部脑回化指数。精神分裂症患者大脑皮层厚度和局部脑回化指数与多脑区的认知功能和行为学有显著相关性。精神分裂症（SZ）患者显示显着的脑结构异常，然而，调节皮质解剖变异的遗传机制及其与疾病表型的相关性仍然是模糊的。我们使用基于表面的方法来表征SZ患者和年龄和性别匹配的健康对照（HC）的结构磁共振成像的解剖变异。在SZ风险基因和来自艾伦人脑图谱的所有合格基因的解剖变异和平均转录谱之间跨皮质区域进行偏最小二乘回归。使用偏相关分析，每个脑区的形态学特征与SZ患者的病理学变量相关。最终分析共纳入203例SZ和201例HC。我们观察到55个区域的皮质厚度，23个区域的体积，7个区域的面积，和55个区域的局部回旋指数（LGI）之间的SZ和HC组的显着变化。4个SZ风险基因和96个合格基因的表达谱显示与解剖变异相关，但多重比较后，相关性不再显著。多个额叶亚区的LGI变异性与SZ的特定症状相关，而涉及注意力/警惕性的认知功能与9个脑区的LGI变异性相关。精神分裂症患者大脑皮层解剖变异与基因转录组谱及临床表型相关
This study examined the relationship between cortical anatomical variation with gene expression and clinical phenotypes of schizophrenia patients. The anatomical features of the brain cortical in patients with schizophrenia exhibit widespread and consistent variation, which is associated with the transcriptome profiles of genes, especially cortical thickness and local gyrification index. Significant relationships found between cortical thickness and local gyrification index with symptomatology and cognitive function involving multiple brain regions of patients with schizophrenia. Schizophrenia (SZ) patients display significant structural brain abnormalities; nevertheless, the genetic mechanisms regulating cortical anatomical variations and their correlation with the disease phenotype are still ambiguous. We characterized anatomical variation using a surface-based method derived from structural magnetic resonance imaging of patients with SZ and age- and sex-matched healthy controls (HCs). Partial least-squares regression was performed across cortex regions between anatomical variation and average transcriptional profiles of SZ risk genes and all qualified genes from the Allen Human Brain Atlas. The morphological features of each brain region were correlated to symptomology variables in patients with SZ using partial correlation analysis. A total of 203 SZ and 201 HCs were included in the final analysis. We observed significant variation of 55 regions of cortical thickness, 23 regions of volume, 7 regions of area, and 55 regions of local gyrification index (LGI) between SZ and HC groups. Expression profiles of 4 SZ risk genes and 96 genes from all qualified genes showed a correlation to anatomical variability, however, after multiple comparisons, the correlations were no longer significant. LGI variability in multiple frontal subregions was associated with specific symptoms of SZ, whereas cognitive function involving attention/vigilance was linked to LGI variability across nine brain regions. Cortical anatomical variation of patients with schizophrenia is associated with gene transcriptome profiles as well as clinical phenotypes.
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影响因子：
5.7
作者：
Alexander-Bloch AF;Shou H;Liu S;Satterthwaite TD;Glahn DC;Shinohara RT;Vandekar SN;Raznahan A
通讯作者：
Raznahan A
影响因子：
4.5
作者：
Nestor, PG;O'Donnell, BF;Shenton, ME
通讯作者：
Shenton, ME
影响因子：
--
作者：
Gur, RE;Cowell, PE;Gur, RC
通讯作者：
Gur, RC
DOI：
10.1073/pnas.1820754116
发表时间：
2019-05-07
影响因子：
11.1
作者：
Morgan, Sarah E.;Seidlitz, Jakob;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.
影响因子：
6.7
作者：
OKASHA, A;MADKOUR, O
通讯作者：
MADKOUR, O